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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Head of Clinical Data Science, Alexion Quantitative Sciences - **Company:** AstraZeneca plc - **Location:** Boston, MA, United States - **Experience:** Expert - **Salary:** $212,994.0 - $319,492.0 - **Contract:** Permanent contract - **Skills:** Artificial Intelligence, Bioinformatics, Clinical Data Repository, Computational Biology, Data Governance, Data Infrastructure, EHealth, Graph Database, Python (Programming Language), Systems Integration, Data Lakes, Information Technology, Data Analytics, Wearables, GXP - **Published:** June 11, 2026 - **Apply:** https://www.indeed.com/viewjob?jk=69aaaff8022c77ca ## About the Role Do you have a Master's degree?, * PhD or master's degree * Data Science, Bioinformatics, Computational Biology, Computer Science, or equivalent experience * Minimum 10 years of pharmaceutical or biotech experience * Experience in a Data Science, Bioinformatics, or AI/ML function * Minimum 6 years managing direct reports in a global setting * Experience integrating multi-omics data (genomics, transcriptomics, proteomics) in drug development and conducting analyses in R, Python, and relevant software * Deep expertise in AI/ML methods and their application to clinical and translational medicine * Experience integrating multi-omics data (genomics, transcriptomics, proteomics) in drug development * Thorough knowledge of regulatory standards: FDA, 21 CFR Part 11, CDISC, GxP * Demonstrated ability to influence strategically and build cross-functional partnerships * Track record of leading AI and data governance in regulated pharmaceutical environments * Experience successfully leading global, cross-functional teams * Strong eye for business and experience influencing and managing budgets Desirable Skills/Experience: * Experience with rare disease drug development and patient stratification strategies * Familiarity with knowledge graphs, graph ML, and mechanism-centered disease representation * Experience with wearables, digital biomarkers, and imaging as clinical endpoints * Experience with indication expansion and AI-driven drug re-purposing programs * Broad experience across multiple therapeutic areas beyond rare diseases * Experience managing significant organisational change and scaling data science functions ## Description Introduction to Role:The Sr Director/Head of Clinical Data Science provides strategic and operational leadership for data science, bioinformatics, and AI/ML functions within the Rare Disease Unit. It drives innovation in clinical development by integrating multi-omics, imaging, and digital health data into unified analytical platforms, establishing robust AI and data governance, and aligning data science strategy with organisational R&D priorities. It owns the future direction of mechanism-centered disease modelling and translational AI within Alexion and sets the vision for the application of innovative statistical and bioinformatics methods. Accountabilities: * Providing strategic leadership for clinical data science, bioinformatics, and AI/ML initiatives across the Rare Disease portfolio, ensuring alignment with R&D objectives. * Leading the development of Clinical Data Science strategy within Alexion, contributing to the enterprise-wide data science and AI strategy, and contributing to the Alexion Quantitative Sciences strategy. * Building and scaling a high-performing cross-functional team spanning AI, bioinformatics, and translational medicine, accelerating study design and data-driven decision-making. * Establishing and coordinating AI and data governance frameworks aligned with regulatory standards (FDA, 21 CFR Part 11, CDISC, GxP), reducing compliance risk across clinical programs. * Driving the integration of clinical, omics, imaging, and commercial data into unified analytical platforms, enabling sophisticated analytics and knowledge generation. * Leading biomarker discovery and validation efforts across multi-omics (transcriptomics, proteomics, genomics) to support patient stratification and therapeutic advancement. * Developing and maintaining data infrastructure - data lakes, knowledge graphs, and wearables pipelines - to create sustainable, scalable capabilities for rare disease research. * Partnering with translational medicine and clinical teams to design innovative Phase 1/2 proof-of-concept strategies incorporating omics and digital health technologies. * Being responsible for the identification and prioritisation of therapeutic targets through AI-enabled clinical and imaging approaches, advancing candidates to IND. * Championing the adoption of digital health solutions, including wearables and imaging, as exploratory and registrational endpoints in clinical trials. * Integrating multi-omics datasets into pharmacokinetic (PK) models, improving prediction accuracy and strengthening dose-response insights for rare disease programs. * Applying AI/ML and omics-driven disease clustering to guide indication prioritisation and drug re purposing opportunities, expanding pipeline value in rare and metabolic diseases. * Serving as a senior leader representing Clinical Data Science in internal governance forums and external collaborations, shaping the strategic direction of data-driven rare disease R&D. * Planning and managing complex departmental budget, including forecasting for quarterly, annual, and multi-year cycles, and input to the Strategic Planning process. * Leading portfolio-level data science capacity management for the R&D unit and contributing to or leading Alexion Quantitative Sciences pivotal initiatives. ## Related Videos - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [Android beyond mobile: Cars, TVs, and Wearables](https://www.wearedevelopers.com/videos/553-android-beyond-mobile-cars-tvs-and-wearables) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Reality and Beyond: Coding a Drone Using {Unity 3D .NET} and ChatGPT AI!](https://www.wearedevelopers.com/videos/702-reality-and-beyond-coding-a-drone-using-unity-3d-net-and-chatgpt-ai) - [Exploring the Potential of Decentraland](https://www.wearedevelopers.com/videos/583-exploring-the-potential-of-decentraland) - [AI in High-Stakes Industries: Lessons Learned](https://www.wearedevelopers.com/videos/100253-ai-in-high-stakes-industries-lessons-learned) ## Related Articles - [Coffee with Developers - Maria Apazoglou - Making AI understandable for all in production](https://www.wearedevelopers.com/magazine/475-coffee-with-developers-maria-apazoglou-making-ai-understandable-for-all-in-production) - [Data Analyst Salary in the UK](https://www.wearedevelopers.com/magazine/278-data-analyst-salary-in-the-uk) - [Navigating the AI Shift](https://www.wearedevelopers.com/magazine/629-navigating-the-ai-shift) - [How to Become an AI Engineer](https://www.wearedevelopers.com/magazine/331-how-to-become-an-ai-engineer) - [What Industries Outside of AI Are Hiring The Most AI Experts?](https://www.wearedevelopers.com/magazine/98-what-industries-outside-of-ai-are-hiring-the-most-ai-experts) - [Data Analyst Salary Austria](https://www.wearedevelopers.com/magazine/275-data-analyst-salary-austria)