> Markdown version of [/jobs/ext/1263407-scientist-senior-scientist-bioanalytical-lc-ms](https://www.wearedevelopers.com/jobs/ext/1263407-scientist-senior-scientist-bioanalytical-lc-ms). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Scientist / Senior Scientist, Bioanalytical LC-MS... - **Company:** Alloy Therapeutics - **Location:** Waltham, MA, United States - **Experience:** Expert - **Salary:** $126,000.0 - $150,000.0 - **Contract:** Permanent contract - **Skills:** Data Analysis, Human Resources Information System (HRIS) - **Published:** July 14, 2026 - **Apply:** https://www.juju.com/job/00000000ggc80y ## About the Role + Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field. + 3+ years (Ph.D) or 10+ years (M.S.) of post-academic experience + Demonstrated experience with LC-MS and high-resolution MS (HRMS) oligonucleotides bioanalysis, including stability, MetID, and protein binding studies. + Comfort working cross-functionally in a discovery environment. Preferred Qualifications + Experience with chemically modified oligonucleotides and/or conjugates. + Ability to interpret LC-MS data in a DMPK and biological context. + Exposure to PK/PD concepts and molecular biology-based analytical technologies (e.g., qPCR, ddPCR). Key Skills & Competencies + LC-MS/MS and LC-HRMS (core expertise) + Oligonucleotide exposure, stability, metabolism, and protein binding + DMPK-relevant data interpretation + Strong troubleshooting ability and scientific judgment + Clear cross-functional communication ## Description We are seeking a hands-on scientist with strong expertise in LC-MS to lead bioanalytical characterization of oligonucleotide therapeutics, focusing on DMPK and biological interpretation. This LC-MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity., + LC-MS-Driven Bioanalysis: Develop and execute LC-MS/MS and LC-HRMS methods for quantitative and structural analysis of oligonucleotides in biological matrices. Design and perform stability, degradation, and Metabolite Identification (MetID) studies to support DMPK. Provide a higher throughput or automated protein binding data (LC-MS Proteomics) . + Exposure & Disposition: Apply LC-MS and other methods to assess oligonucleotide-protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure. + DMPK & Biological Integration: Interpret LC-MS data within a DMPK context, collaborating with cross-functional teams to link findings with PK, PD, and biological readouts (e.g., target knockdown, gene expression). + Data Analysis & Communication: Perform quantitative LC-MS data analysis, troubleshoot analytical issues, and clearly communicate analytical and DMPK insights to inform decision-making. ## Related Videos - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail) - [What if your HR software adapted to you, not the other way around?](https://www.wearedevelopers.com/videos/100259-what-if-your-hr-software-adapted-to-you-not-the-other-way-around) - [Forecasting Cyber Attacks with Glassdoor Reviews - Lianne Potter](https://www.wearedevelopers.com/videos/2143-forecasting-cyber-attacks-with-glassdoor-reviews-lianne-potter) - [Building APIs for Agents vs Systems. Is MCP the answer?](https://www.wearedevelopers.com/videos/100291-building-apis-for-agents-vs-systems-is-mcp-the-answer) - [Data Science on Software Data](https://www.wearedevelopers.com/videos/162-data-science-on-software-data) ## Related Articles - [Data Analyst Salary in the UK](https://www.wearedevelopers.com/magazine/278-data-analyst-salary-in-the-uk) - [Data Analyst Salary in Switzerland](https://www.wearedevelopers.com/magazine/276-data-analyst-salary-in-switzerland) - [Data Analyst Salary Austria](https://www.wearedevelopers.com/magazine/275-data-analyst-salary-austria) - [Data Analyst Salary Germany](https://www.wearedevelopers.com/magazine/277-data-analyst-salary-germany) - [Best Companies to work for in London: Top 25 Companies in 2023](https://www.wearedevelopers.com/magazine/187-best-companies-to-work-for-in-london-top-25-companies-in-2023) - [Data Engineer Salary UK](https://www.wearedevelopers.com/magazine/253-data-engineer-salary-uk)