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# Senior Scientist, Discovery Technologies

- **Company:** Flagship Pioneering, Inc.
- **Location:** Cambridge, MA, United States
- **Experience:** Expert
- **Salary:** $126,000.0 - $181,500.0
- **Contract:** Permanent contract
- **Skills:** Data Analysis, Experimental Data
- **Published:** July 27, 2026
- **Apply:** https://www.indeed.com/viewjob?jk=d4544d03f4c2963f

## About the Role

* Ph.D. in molecular biology, systems biology, chemical biology, or a similar field with 5+ years of industry or postdoctoral experience.

 * End-to-end experience with small molecule screening from library design, including optimization of DNA tags for amplification, quantitation and sequencing, to screening, next-gen sequencing, to data analysis.

 * Experience managing contract research organizations (CROs).

 * Nice to have: cheminformatics experience, on-DNA and off-DNA hit validation experience with DNA-encoded positive control and library compounds, surface display technologies, droplet-based screening and/or microfluidics, and single-cell or genomics methods.

 * Motivated team-player and independent force-of-nature with strong organizational and written/verbal communication skills., We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.

## Description

We are seeking a motivated and highly collaborative Senior Scientist to join FL129's growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have strong track record of scientific and technical innovation in molecular biology and small molecule screening, including experience adapting screens to cell- or surface-displayed protein targets. Additional experience with or exposure to yeast surface display, single-cell or genomics methods, and cheminformatics are preferred. The ideal teammate will be highly adaptable, have strong organizational and communication skills, and will thrive in a highly collaborative and multidisciplinary environment., * Technology development, aligned with FL129's core strategic goals. This role is among the first hires, and we're looking for someone who thinks critically and will influence the company's scientific direction.

 * Design, construction, and experimental testing of custom target/variant libraries, including binding assays against cell- or surface-displayed protein targets

 * Optimize existing workflows and establish best experimental and documentation practices to enable platform excellence.

 * Ensuring rapid and accurate turnaround of data to drive achievement of key project goals.

 * Translate experimental data into meaningful insights and present results at team meetings., * Opportunity to lay the scientific foundation of a transformative platform company as an early employee.

 * Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests.

 * Weekly lunches, monthly social events, and community lunchroom with free snacks, coffee, all embedded in a vibrant community of scientists and entrepreneurs across multiple Flagship Pioneering portfolio companies.


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