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# Senior Director, Discovery Sciences & Technologies

- **Company:** Gilead Sciences Inc.
- **Location:** San Mateo, CA, United States
- **Experience:** Expert
- **Salary:** $261,375.0 - $338,250.0
- **Contract:** Permanent contract
- **Skills:** Data Analysis, Decision Support Systems, Data Analytics
- **Published:** July 30, 2026
- **Apply:** https://www.businessworkforce.com/job.asp?id=3336330052&tx=ZT2322THT&pt=1&aff=0B19D771-A501-4A5E-8338-2A822B784D54&utm_source=Job%20Feed&utm_medium=textkernel&utm_campaign=DE&utm_term=0B19D771-A501-4A5E-8338-2A822B784D54

## About the Role

* PhD in biochemistry, enzymology, biophysics or a related discipline with a minimum of 15+ years of drug discovery experience in an industrial research environment.
 * Deep expertise in protein-ligand interactions, supported by strong experience with biophysical and cell-based technologies.
 * Demonstrated success in developing and deploying biochemical and cellular assays for target validation, lead generation, and SAR driven optimization.
 * Proven track record of advancing discovery programs from HTS to development candidate nomination.
 * Experience with mass spectrometry-based approaches, and expertise in covalent inhibitors and degrader modalities, is highly desirable.
 * Established ability to lead, mentor, and develop senior level scientists and to drive impact in a highly matrixed organization.
 * Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to diverse scientific and non-scientific audiences.

## Description

DST scientists design and execute rigorous, quantitative, and physiologically relevant in vitro biochemical and cellular assays that underpin decision-making throughout discovery. In this highly matrixed environment, the Senior Director will be expected to work effectively across functions - including medicinal chemistry, protein therapeutics, structural biology, computational/data sciences and therapeutic biology teams - to advance transformational therapies into clinical development for patients., * Lead and inspire a high-performing team responsible for developing biochemical, biophysical, and cellular pharmacology assays across all therapeutic areas and modalities.

 * Establish and execute assay and screening strategies that enable target discovery, hit identification, and lead optimization, while proactively identifying rate-limiting steps and key decision points.
 * Apply and integrate diverse biophysical and cellular approaches to drive deep mechanistic understanding of target engagement, pathway modulation, and inhibitor behavior.
 * Drive the adoption and internal development of next-generation lead-generation technologies, including novel assay platforms, automation, data analytics, and innovative screening methodologies, to maintain state-of-the-art discovery capabilities
 * Evaluate and influence external technologies, platforms, and innovations in support of in-licensing, partnerships, and strategic collaborations
 * Provide clear scientific direction, critical data interpretation, and decision support at project teams and governance forums.
 * Manage resources effectively across multiple concurrent programs to ensure efficient progression of programs across Gilead's research portfolio.
 * Mentor, develop, and empower scientific leaders and emerging talent, fostering a culture of scientific excellence, innovation, accountability, and collaboration., * Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.
 * Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.
 * Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.


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