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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Scientist - Process Translation... - **Company:** The Lilly Company - **Location:** Indianapolis, IN, United States - **Experience:** Experienced - **Salary:** $66,000.0 - $171,600.0 - **Contract:** Permanent contract - **Skills:** Application Programming Interfaces (APIs), Data Analysis, Enterprise Software Applications - **Published:** May 14, 2026 - **Apply:** https://www.juju.com/job/00000000g3o7ku ## About the Role + BS or MS in Chemical Engineering or a closely related discipline + 4+ years of industry experience - in pharmaceutical process development, pilot plant operations, or chemical manufacturing. + Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Additional Skills and Preferences: + Deep technical interest and understanding in the field of Chemical Engineering. + Direct hands-on experience with operating kilo-scale or pilot-scale chemical processing equipment. + Experience with any of the following software packages: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks. + Experience with crystallization development including polymorph control, nucleation/growth kinetics, seeding strategies, and PSD control. + Expertise on filtration modeling and ability to fit model parameters from lab data and apply to pilot equipment sizing and optimization. + Highly motivated, able to learn rapidly, and demonstrates strong attention to detail. + A good understanding of FDA guidelines and cGMP requirements. + Ability to prioritize multiple activities and manage ambiguity. + Demonstrated ability to drive projects and accept change. + Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams + Problem-solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges. + Ability to work cross-functionally across disciplines and levels with process chemists, analytical chemists, chemical technicians, safety and quality representatives. ## Description The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase-appropriate control strategies, and ensures right-first-time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.) Through cross-functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long-term business success. In the Foundry Construction and Project Delivery/Startup Phase (2026 to 2028), roles will be fluid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readiness, support the project delivery, and build the site culture. Success will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry transitions from design to startup and ultimately to steady-state operations and continuous improvement. This period presents a unique opportunity for learning, growth, and making a lasting impact. We are seeking passionate and agile engineers to join the PTE team and help bring the Lilly Medicine Foundry's vision to life. Responsibilities In this role, the Engineer will be responsible with facilitating the transfer of chemical processes, under appropriate supervisory guidance, from development laboratories to pilot plant operations (including kilo-scale or pilot-scale production). This enables the successful transition to early-phase cGMP manufacturing of kilogram quantities of API required for clinical trial supply. + Operate and troubleshoot kilo-scale equipment including multi-purpose reactors, filtration systems, drying equipment (including AFD and tray dryer). + Apply chemical engineering principles (heat/mass transfer, reaction kinetics, thermodynamics, fluid dynamics) to scale-up calculations and equipment sizing. + Develop and apply appropriate cake filtration models to predict filtration rate, cake resistance, and deliquoring performance. Design and execute filtration wash studies. + Apply appropriate modeling or semi-empirical approaches to predict and control particle size distribution (PSD) during crystallization. + Actively involved in receiving chemical process from early phase process research and development labs and evaluating the safety of the incoming procedures in collaboration with the chemist and safety group. · Documentation: Author, review technical documents, including standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports. + Perform and document Definitive Lab Trials of crystallization step to confirm plant readiness. + Perform familiarization reactions to ensure plant readiness of process steps with focus on crystallization and filtration at the Lilly Medicine Foundry. + Ordering and staging process-related GMP consumables and equipment parts for kilolab runs. + Efficient with summarizing and presenting experimental results and challenges. + · Analyze data to make fact-based decisions. + · Maintain a well-organized and detailed lab notebook to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs. + Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures. + Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non-conformances. + · Demonstrate engagement and employ a quality mindset in all endeavors by proactively identifying quality issues and communicating appropriately., + May be required to provide support outside of normal working hours including nights or weekends. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. ## Related Videos - [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail) - [Creating Europe's AI Moment – Now or Never](https://www.wearedevelopers.com/videos/100059-creating-europe-s-ai-moment-now-or-never) - [Rest API Antipatterns](https://www.wearedevelopers.com/videos/100208-rest-api-antipatterns) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Data Science, ML & AI in the Oil and Gas Industry at NDT Global - Dr. Katja Träumner](https://www.wearedevelopers.com/videos/1308-data-science-ml-ai-in-the-oil-and-gas-industry-at-ndt-global-dr-katja-traumner) - [Data Science on Software Data](https://www.wearedevelopers.com/videos/162-data-science-on-software-data) ## Related Articles - [Now is the time for industrialized software development](https://www.wearedevelopers.com/magazine/601-now-is-the-time-for-industrialized-software-development) - [How to Become an AI Engineer](https://www.wearedevelopers.com/magazine/331-how-to-become-an-ai-engineer) - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Where To Find Software Engineering Jobs](https://www.wearedevelopers.com/magazine/396-where-to-find-software-engineering-jobs) - [What Are Large Language Models?](https://www.wearedevelopers.com/magazine/304-what-are-large-language-models) - [Coffee with Developers - Maria Apazoglou - Making AI understandable for all in production](https://www.wearedevelopers.com/magazine/475-coffee-with-developers-maria-apazoglou-making-ai-understandable-for-all-in-production)