> Markdown version of [/jobs/ext/166895-senior-manager-mes-system](https://www.wearedevelopers.com/jobs/ext/166895-senior-manager-mes-system). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Senior Manager MES System - **Company:** Gilead Sciences Inc. - **Location:** La Verne, CA, United States - **Experience:** Expert - **Salary:** $153,935.0 - $199,210.0 - **Contract:** Permanent contract - **Skills:** Artificial Intelligence, Data Analysis, DevOps, IT Management, Iq/oq/pq, System Availability, Technical Debt, Information Technology, GXP - **Published:** May 24, 2026 - **Apply:** https://www.juju.com/job/00000000g20k4z ## About the Role + Bachelor's degree in IT, Engineering, Computer Science, ora relateddiscipline (or equivalent experience). + 10+ years of experience supporting or leading MES or manufacturing systems in a regulated (GxP) environment. + Demonstrated experience owning and operating mission-critical platforms in a 24x7 environment. + Proven people management experience leading technical teams. + Strong working knowledge of PAS-X MES platforms. Preferred Qualifications + ExperienceestablishingDevOps or product-centric operating models in regulated manufacturing. + Direct accountability for audits, inspections, and regulatory interactions related to MES. + Experience managing both run and change budgets for large enterprise platforms. + Knowledge of SAP-MES integration, ISA-95 / S88, and OT/automation interfaces. + Certification inPAS-XMES systems. + Experience with leveraging AI/ML. + Strong executive communication and stakeholder management skills. ## Description Platform Ownership & Strategy + Own the MES platform end-to-end, including PAS-X core, integrations, infrastructure, and supporting services. + Define and execute the MES platform strategy aligned with site and enterprise manufacturing priorities. + Establish andmaintaina multi-year MES roadmap covering sustainment, modernization, scalability, and technical debt reduction. + Serve as the single accountable decision owner for MES platform architecture, risk, and trade-offs. DevOps & Operational Excellence + Own the DevOps operating model for MES, including incident, problem, change, release, and deployment management. + Ensure high availability, performance, and reliability of MES in a 24x7 GMP manufacturing environment. + Lead root cause analysis for critical incidents and drive systemic corrective and preventive actions. + Oversee system upgrades, patches, enhancements, and infrastructure changes with minimal manufacturing disruption. + Define andmonitoroperational SLAs, KPIs, and reliability metrics. Compliance, Validation & Quality + Own the MES validation strategy (IQ/OQ/PQ) in alignment withGxP, GAMP 5, and 21 CFR Part 11 requirements. + Ensure continuousinspectionreadiness through strong documentation, controls, and operating discipline. + Partner with Quality to ensure compliance is embedded in solution design, delivery, and operations. + Accountable for audit readiness, support, responses, observations, and remediation related to MES. Delivery & Continuous Improvement + Govern intake, prioritization, and delivery of MES enhancements and business requests. + Balancerunand change demand to ensure predictable delivery without compromising system stability. + Drive standardization, simplification, and reuse across MES workflows and configurations. + Identifyand sponsor opportunities for automation, analytics, and AI-enabled improvements. People Leadership + Lead, coach, and develop a multi-disciplinary MES DevOps and development team. + Set clear roles, expectations, and accountability across support, development, and delivery functions. + Build team capability and resilience through succession planning, cross-training, and skills development. + Foster a culture of ownership, quality, continuous improvement, and collaboration. Stakeholder & Financial Management + Serve as a senior interfacetoManufacturing, Packaging, Quality, Automation, Warehouse, and IT leadership. ## Related Videos - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [From DevOps to Scaled DevOps: How We’re Rebuilding Continuous Delivery as a Platform](https://www.wearedevelopers.com/videos/100018-from-devops-to-scaled-devops-how-we-re-rebuilding-continuous-delivery-as-a-platform) - [Beyond GPT: Building Unified GenAI Platforms for the Enterprise of Tomorrow](https://www.wearedevelopers.com/videos/1525-beyond-gpt-building-unified-genai-platforms-for-the-enterprise-of-tomorrow) - [DevOps Maturity Check – a way to balance autonomy and alignment](https://www.wearedevelopers.com/videos/58-devops-maturity-check-a-way-to-balance-autonomy-and-alignment) - [#90DaysOfDevOps - The DevOps Learning Journey](https://www.wearedevelopers.com/videos/548-90daysofdevops-the-devops-learning-journey) - [Effective Machine Learning - Managing Complexity with MLOps](https://www.wearedevelopers.com/videos/185-effective-machine-learning-managing-complexity-with-mlops) ## Related Articles - [From developer to manager – what does it take to become an engineering manager?](https://www.wearedevelopers.com/magazine/42-from-developer-to-manager-what-does-it-take-to-become-an-engineering-manager) - [Everything a Developer Needs to Know About MCP with Neo4j](https://www.wearedevelopers.com/magazine/604-everything-a-developer-needs-to-know-about-mcp-with-neo4j) - [Now is the time for industrialized software development](https://www.wearedevelopers.com/magazine/601-now-is-the-time-for-industrialized-software-development) - [A Guide to Green Tech and Green IT Careers](https://www.wearedevelopers.com/magazine/374-a-guide-to-green-tech-and-green-it-careers) - [Best Companies to Work For in Germany: Top 25 Companies in 2023 ](https://www.wearedevelopers.com/magazine/33-best-companies-to-work-for-in-germany-top-25-companies-in-2023) - [Top-Paying Tech Jobs (with Salaries)](https://www.wearedevelopers.com/magazine/372-top-paying-tech-jobs-with-salaries)