> Markdown version of [/jobs/ext/1734889-principal-systems-engineer](https://www.wearedevelopers.com/jobs/ext/1734889-principal-systems-engineer). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Systems Engineer - **Company:** Baxter International Inc. - **Location:** Milwaukee, WI, United States - **Experience:** Expert - **Salary:** $128,000.0 - $176,000.0 - **Contract:** Permanent contract - **Skills:** Systems Engineering, Microsoft Azure, MATLAB, Scaled Agile Framework, Software Engineering, Software Requirements Analysis, Systems Architecture, Trackwise, Polarion - **Published:** July 2, 2026 - **Apply:** https://baxter.wd1.myworkdayjobs.com/baxter/job/Milwaukee-Wisconsin/Sr-Principal-Systems-Engineer_JR-204345-1/apply ## About the Role * Bachelor's Degree (Mechanical, Electrical, Software, Biomedical Engineering or comparable technical subject area) * 8+ years' of engineering experience on medical devices. * Knowledge in ISO 14971 Application of Risk Management to Medical Devices * Knowledge of IEC 60601 Safety Compliance of Medical Devices * Ability to apply systems engineering principles in Agile SAFe framework by supporting the Product Owner in Epic, Feature and Story development/definition and backlog prioritization * Experience using tools such as MATLAB (MBSE), Azure DevOps, Polarion, Trackwise preferred. * Strong interpersonal skills with the ability to lead and work collaboratively with others in a team environment * Able to work in the absence of complete information and make timely decisions performing with great attention to detail * Excellent verbal and written communication, especially relating to clear, concise, and verifiable requirements. * Strategic problem solver, organized and able to progress on many different tasks in parallel * Able to plan, estimate and accurately track deliverables * Fundamental understanding of Hardware & Software engineering * Adaptive, open to change and continuously looks for ways to improve and simplify sophisticated work * Prior experience on Resting ECG devices (AFE, Cardiographs) is a plus., Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment visa at this time. ## Description As a Sr. Principal Systems Engineer, you will be a part of a multidisciplinary new product development team! This position will understand and define customer needs; product functionality and performance requirements; product architecture, constraints and trade-offs; design and interface requirements, of new products being developed. You will support the overall design of the final product and responsible for all risk management activities to ensure a safe and effective product., * Manage and own the technical roadmap for product families, integrate technical roadmaps with Upstream Marketing product roadmaps * Work with Program Management, Upstream Marketing and Customers to plan new development, initiate product change activities, understand & translate market needs into technical product requirements & workflows. Work with cross functional team members (e.g., Marketing and Clinical personnel) to translate user needs into system requirements. Serve as liaison VOC from Marketing to Engineering. * Work with Engineering Project Management to define and scope projects to achieve program goals. Participate as a member of project teams for the assigned program. * Lead development of Design Inputs and Digital Interface Requirements. * Develop User and Clinical Workflows to drive requirement analysis * Own System Architecture * Lead engineering resources (Electrical, Mechanical, and Software) in the decomposition of system requirements to derived requirements. * Contributes to resolution of competing constraints among inter-related functions (e.g., engineering, manufacturing, regulatory, marketing) required to deliver products to market. Lead Decision Making using tools such as Decision Matrices to evaluate trade-offs. * Resolves interface issues and have the ability to document theory of operations of complex medical product designs. * Work with verification engineers to define test strategies for the development of verification plans and validation plans using requirement tracing methods. * Owner of the Design History File (DHF). Responsible for ensuring technical product requirements are clearly & thoroughly documented, and verified & validated. This includes the following: * Ensures usability requirements are adequately incorporated per IEC 62366. * Lead technical resource for Risk Management analysis activities per IEC 14971 including capturing hazards, mitigations, and residual risk determination. * Lead Coordination and review of system and design level requirements to ensure they adequately meet system requirements, market needs, serviceability and manufacturability of the product. * Member of multi-functional support team; duties as needed include serving as critical issue point-person, lead product support meetings, participate in CAPA activities, asist with complaint & post-market investigations. * Oversee platform-based product designs that meet needs for multiple portfolios by coordinating shared needs and requirements. ## Related Videos - [From Bedside Beeps to Interoperable Bytes – Getting your medical devices ready to talk the IEEE 11073 language](https://www.wearedevelopers.com/videos/771-from-bedside-beeps-to-interoperable-bytes-getting-your-medical-devices-ready-to-talk-the-ieee-11073-language) - [Leveraging Large Language Models for Legacy Code Translation: Challenges and Solutions](https://www.wearedevelopers.com/videos/1157-leveraging-large-language-models-for-legacy-code-translation-challenges-and-solutions) - [Building a hypercar from scratch](https://www.wearedevelopers.com/videos/607-building-a-hypercar-from-scratch) - [ZEISS & Microsoft - Building the Next Generation Medical Ecosystem in the Cloud](https://www.wearedevelopers.com/videos/424-zeiss-microsoft-building-the-next-generation-medical-ecosystem-in-the-cloud) - [Software stack under and over the hood of the fastest accelerating car in the world](https://www.wearedevelopers.com/videos/221-software-stack-under-and-over-the-hood-of-the-fastest-accelerating-car-in-the-world) - [Model Based Systems Engineering in an Agile Product Development Process](https://www.wearedevelopers.com/videos/68-model-based-systems-engineering-in-an-agile-product-development-process) ## Related Articles - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Where To Find Software Engineering Jobs](https://www.wearedevelopers.com/magazine/396-where-to-find-software-engineering-jobs) - [Top-Paying Tech Jobs (with Salaries)](https://www.wearedevelopers.com/magazine/372-top-paying-tech-jobs-with-salaries) - [The 12 Best Jobs for Software Engineers](https://www.wearedevelopers.com/magazine/401-the-12-best-jobs-for-software-engineers) - [What is Software Engineering?](https://www.wearedevelopers.com/magazine/289-what-is-software-engineering) - [Data Engineer Salary UK](https://www.wearedevelopers.com/magazine/253-data-engineer-salary-uk)