> Markdown version of [/jobs/ext/2024473-sr-principal-engineer-mes-systems](https://www.wearedevelopers.com/jobs/ext/2024473-sr-principal-engineer-mes-systems). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Sr Principal Engineer - MES Systems - **Company:** Eli Lilly and Company - **Location:** Richmond, VA, United States - **Experience:** Expert - **Salary:** $126,000.0 - $184,800.0 - **Contract:** Permanent contract - **Skills:** Application Programming Interfaces (APIs), Data Integration, Release Management, Cloud Services, Syncade, GXP - **Published:** August 11, 2026 - **Apply:** https://www.biospace.com/logon?PipelinedPage=%2Fjob%2F3067470%2Fsr-principal-engineer-mes-systems%3FAction%3DContinueJobApplication%23application-form ## About the Role * Pharmaceutical Manufacturing Regulatory compliance knowledge and experience (cGMP) * Effective people and team leadership skills * Ability to manage and contribute to multiple concurrent activities and adapt to changes in priorities. * Ability to cross functionally collaborate. * Excellent written and oral communication skills. * Demonstrate creativity, analytical thinking, and the ability to troubleshoot and solve problems. * Knowledge of cloud solutions and architecture * History of promoting safety and maintaining a safe work environment * Establish a strong site culture based in Lilly values, expectations, and operational excellence standards. * Demonstrated adhere adherence to compliance for internal and external quality guidance. * Demonstrated and promote Operational Excellence * Effectively encourage knowledge sharing and education * Evaluate and translate functional requirements into technical solutions. * Ability to problem solving and work through manufacturing situations. Have experience serving as an escalation contact with vendor(s) * Proven technical ability to develop and integrate MES solutions, * Bachelor's Degree in IT, Engineering, or related technical field, * 10+ years of strong experience with MES system implementations and Data Integration preferably Syncade/Delta V MES * Professional experience working in a GXP, regulated environment ## Description The Sr Principal Engineer - MES System will part of one of our new state of the art API facility MES team tasked with developing standard approaches and components that will used to build MES recipes and integration throughout Lilly's network of new Active Pharmaceutical Ingredients (API) sites. The role will assist local teams in the Design, Development, Delivery and CSV of the MES solutions for the new facilities. This role will report to the MQ IT Leader for new facilities., * Develop and integrate MES common and site-specific components. * Benchmark on innovative solutions (external and internal to Lilly) * Dynamically adapt road map to site evolution/strategic directions, and new trends/issues. * Establish a strong site culture based in Lilly values, expectations, and operational excellence standards. * Support MES solutions start up activities. * Work with site resources towards replication & standardization to drive value and implement the appropriate technical solutions. * Evaluate emerging technologies and implications to existing Lilly footprint. * Maintain open communication with MES vendor(s) to address needs in standard solution or via functional packs. * Evaluate and translate functional requirements into technical solutions. * Ensure project and/or validation documentation is maintained during lifecycle & release management. * Develops \ assists in the creation and maintenance of the MES interfaces with other Lilly systems. *, * Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate other inputs (production schedules, shutdowns, etc.). Occasional extended hour and / or off-hour work may be required. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. ## Related Videos - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [Leverage Cloud Computing Benefits with Serverless Multi-Cloud ML ](https://www.wearedevelopers.com/videos/78-leverage-cloud-computing-benefits-with-serverless-multi-cloud-ml) - [ZEISS & Microsoft - Building the Next Generation Medical Ecosystem in the Cloud](https://www.wearedevelopers.com/videos/424-zeiss-microsoft-building-the-next-generation-medical-ecosystem-in-the-cloud) - [Why make use of an integration platform in today's software developments and infrastructure?](https://www.wearedevelopers.com/videos/758-why-make-use-of-an-integration-platform-in-today-s-software-developments-and-infrastructure) - [Cloud-nativeApplications- What’s the buzz about](https://www.wearedevelopers.com/videos/55-cloud-nativeapplications-what-s-the-buzz-about) - [Next Level Enterprise Architecture: Modular, Flexible, Scalable, Multichannel and AI-Ready?](https://www.wearedevelopers.com/videos/1017-next-level-enterprise-architecture-modular-flexible-scalable-multichannel-and-ai-ready) ## Related Articles - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Best Companies to work for in London: Top 25 Companies in 2023](https://www.wearedevelopers.com/magazine/187-best-companies-to-work-for-in-london-top-25-companies-in-2023) - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Coffee with Developers - Maria Apazoglou - Making AI understandable for all in production](https://www.wearedevelopers.com/magazine/475-coffee-with-developers-maria-apazoglou-making-ai-understandable-for-all-in-production) - [Software Engineer Salary London](https://www.wearedevelopers.com/magazine/252-software-engineer-salary-london) - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers)