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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Senior Enterprise Architect - Remote/Nationwide - **Company:** Signature Performance, Inc. - **Location:** Columbia, SC, United States (Remote available) - **Experience:** Expert - **Salary:** $195,000.0 - $213,000.0 - **Contract:** Permanent contract - **Skills:** Cerner, Artificial Intelligence, Amazon Web Services, ASC X12 Standards, Application Portfolio Management, Microsoft Azure, Health Informatics, Cloud Computing, Cloud Computing Security, Cloud Engineering, Cyber Security, Continuous Integration, Data Architecture, Data Governance, Data Integration, Enterprise Architecture Framework, Identity and Access Management, Interoperability, Information Systems Security Architecture Professional, Machine Learning, Cloud Services, Zero Trust Network Access, Software Vulnerability Management, Enterprise Data Management, EHR Systems, Fast Healthcare Interoperability Resources, Multi-Cloud, Technical Debt, HybridCloud, Cloudformation, Togaf, Event Driven Architecture, Containerization, Kubernetes, Information Technology, Health Level Seven International, Bicep, Cloud Migration, Api Design, Terraform, Devsecops, Api Management, Enterprise Service Bus, Microservices - **Published:** August 12, 2026 - **Apply:** https://diversityjobs.com/main/sendform/8/8/28176/1/17910851?backUrl=%2Fcareer%2F17910851%2FSenior-Enterprise-Architect-Remote-Nationwide-South-Carolina-Columbia ## About the Role You are a person who loves to drive enterprise-wide architecture initiatives that align business goals with secure, scalable, and compliant technology solutions. We need someone who can work as a trusted advisor to executive leadership and partner with stakeholders to establish architecture standards, governance processes, and technology roadmaps that support healthcare operations, government requirements, cloud modernization, and innovation. In the role of Senior Enterprise Architect, you will be responsible for defining and executing enterprise technology strategy across healthcare and regulated cloud environments, with a strong focus on FedRAMP, HIPAA, healthcare interoperability, security, compliance, and digital transformation * Tell us about your experience in Enterprise Architecture, Solution Architecture, or Technology Strategy. * Are you a team player and a self-motivator? * What is your experience with conducting business in a way that is credit to a company? * We are counting on you to manage multiple projects using your problem-solving skills. * We are looking for someone UNCOMMON. What is uncommon about you? Are you highly committed? Are you team-oriented? Do you value professionalism, trust, honesty, and integrity? If so, we cannot wait to meet you., * Bachelor's Degree in Computer Science, Information Technology, Engineering, Healthcare Informatics, or related discipline. * 12+ years of progressive IT experience. * 7+ years in Enterprise Architecture, Solution Architecture, or Technology Strategy leadership roles. * Experience supporting healthcare payer, provider, or healthcare technology organizations. * Proven experience designing and implementing FedRAMP-compliant cloud solutions. * Experience leading enterprise-scale cloud transformation and modernization programs. * Experience working directly with executive leadership and regulatory stakeholders. Enterprise Architecture * TOGAF or equivalent architecture framework expertise. * Business capability modeling and technology road mapping. * Application portfolio management and rationalization. Cloud Platforms * Microsoft Azure Government * Azure Landing Zones * AWS GovCloud * Kubernetes and container platforms * Infrastructure as Code (Terraform, ARM, Bicep, CloudFormation) Security & Compliance * FedRAMP Moderate/High * NIST SP 800-53 * NIST CSF * HIPAA/HITECH * HITRUST * FISMA * Zero Trust Architecture * SOC 2 Healthcare Technologies * Facets (preferred) * Epic, Cerner, or other EHR platforms * HL7 * FHIR * X12 Transactions * Healthcare Data Warehousing * Population Health Platforms Modern Technology Practices * DevSecOps * CI/CD * API Management * Microservices * Event-Driven Architecture * AI and Advanced Analytics Key Competencies * Executive presence and communication * Strategic technology planning * Regulatory and compliance expertise * Healthcare domain knowledge * Cloud architecture leadership * Security-first mindset * Business and financial acumen * Stakeholder management * Organizational influence * Risk assessment and governance * Innovation and digital transformation leadership Preferred Requirements: * Master's Degree preferred. * TOGAF Certified * Microsoft Certified: Azure Solutions Architect Expert * Microsoft Certified: Cybersecurity Architect Expert * AWS Certified Solutions Architect -- Professional * AWS Security Specialty * Certified Information Systems Security Professional (CISSP) * Certified Cloud Security Professional (CCSP) * HITRUST CCSFP * Project Management Professional (PMP) ## Description Enterprise Architecture Strategy * Define and maintain the enterprise architecture vision, principles, standards, and target-state architecture. * Develop multi-year technology roadmaps supporting healthcare and government-regulated business objectives. * Align technology investments with organizational goals, compliance requirements, and operational priorities. * Lead enterprise modernization initiatives, including cloud transformation and platform consolidation. FedRAMP & Regulatory Compliance Leadership * Architect systems and processes compliant with FedRAMP Moderate and High baselines. * Ensure alignment with NIST 800-53, NIST Cybersecurity Framework, FISMA, and federal cloud security requirements. * Collaborate with compliance, security, legal, and audit teams to maintain regulatory adherence. * Support Authority to Operate (ATO) initiatives and security assessment activities. * Guide implementation of continuous monitoring, vulnerability management, and risk mitigation strategies. Healthcare Architecture & Interoperability * Design enterprise solutions supporting HIPAA, HITECH, CMS, and state healthcare regulations. * Lead architecture strategies for healthcare platforms, payer systems, provider systems, population health, and member engagement capabilities. * Drive interoperability initiatives utilizing: + HL7 + FHIR + X12 EDI + API-based healthcare integrations * Develop enterprise data architecture supporting clinical, claims, eligibility, enrollment, and member data domains. * Support data governance, privacy, and healthcare information security initiatives. Cloud & Infrastructure Architecture * Develop cloud adoption and migration strategies using: + Microsoft Azure Government + Azure Commercial + AWS GovCloud + AWS Commercial * Establish cloud governance, security, networking, and operational frameworks. * Lead hybrid-cloud and multi-cloud architecture initiatives. * Drive infrastructure modernization and platform standardization efforts. Security Architecture * Partner with Security and Risk teams to establish Zero Trust architecture strategies. * Ensure solutions incorporate: + Identity and Access Management (IAM) + Privileged Access Management (PAM) + Data encryption + Endpoint security + Security monitoring and incident response * Evaluate security architecture designs and ensure compliance with organizational security policies. Data & Integration Architecture * Define enterprise data management and integration strategies. * Develop API-first architecture standards and integration patterns. * Establish standards for: + Enterprise Service Bus (ESB) + Event-driven architecture + API Management + Healthcare data exchange * Support advanced analytics, AI, machine learning, and reporting initiatives. Architecture Governance * Chair or participate in Architecture Review Boards (ARB). * Establish architecture decision records (ADRs), standards, and reference architectures. * Review solution architectures for alignment with enterprise standards. * Monitor technology portfolio health and technical debt reduction initiatives. Leadership & Mentorship * Provide leadership and mentoring to Enterprise Architects, Solution Architects, and Engineering teams. * Influence senior stakeholders and executive leadership on strategic technology decisions. * Collaborate with business and technology leaders to prioritize enterprise initiatives. * Build strong partnerships with cloud providers, healthcare partners, and government agencies. ## Related Videos - [Back(end) to the Future: Embracing the continuous Evolution of Infrastructure and Code](https://www.wearedevelopers.com/videos/440-back-end-to-the-future-embracing-the-continuous-evolution-of-infrastructure-and-code) - [Next Level Enterprise Architecture: Modular, Flexible, Scalable, Multichannel and AI-Ready?](https://www.wearedevelopers.com/videos/1017-next-level-enterprise-architecture-modular-flexible-scalable-multichannel-and-ai-ready) - [ZEISS & Microsoft - Building the Next Generation Medical Ecosystem in the Cloud](https://www.wearedevelopers.com/videos/424-zeiss-microsoft-building-the-next-generation-medical-ecosystem-in-the-cloud) - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) ## Related Articles - [What Are The Top Skills Required For Azure Developers?](https://www.wearedevelopers.com/magazine/77-what-are-the-top-skills-required-for-azure-developers) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Events like RSAC Get You CISOs. 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