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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Machine Learning Scientist - **Company:** Adaptive Biotechnologies - **Location:** Seattle, WA, United States (Remote available) - **Salary:** $183,400.0 - $275,000.0 - **Contract:** Permanent contract - **Skills:** Training Data, Hospital Information Systems, Computational Biology, Data Files, Experimental Data, Python (Programming Language), Machine Learning, Language Modeling, Scripting, Graphics Processing Unit (GPU), Performance Testing, Pytorch, Deep Learning, Model Validation, Data Strategy, Information Technology, Hardware Infrastructure, Software Version Control - **Published:** August 14, 2026 - **Apply:** https://www.careerbuilder.com/job-details/principal-machine-learning-scientist-seattle-wa--5ca46bb6-56c9-48b4-8545-f04dee57d7f0 ## About the Role * PhD in a quantitative discipline (e.g. Machine Learning, Computational Biology, Computer Science, etc.) + 12 years progressive experience in machine learning, applied statistics or related field in a life sciences or biotech environment or similar combination of education and experience; an advanced degree preferred. * Masters + 15 years of progressive experience, or * Bachelors + 17 years of progressive experience * Progressive experience in the conception, development and deployment of deep learning methods including substantial hands-on model development * Demonstrated track record of innovating and implementing novel machine learning solutions to biological problems, as demonstrated by publications, conference papers, patents, or delivered products. * Deep expertise in python and modern ML tooling (PyTorch preferred) * Experience with version control and ML experiment tracking * Proven ability to independently define, scope, and execute complex technical research problems. * Excellent written and verbal communication skills, with ability to present highly technical material to diverse audiences. * Exceptional depth in deep learning architecture design and implementation. * Comfortable operating at the frontier of both ML and immunology. * Strategic thinker capable of influencing technical direction across teams. * Driven by impact: motivated to see models transition from research to clinical and commercial application. Preferred * Experience in one or more of the following areas desired: * Protein structure prediction * Protein design and generative modeling * Protein language models and large-scale foundation models * Working with large-scale biological datasets * Immunology and immune receptor specificity (antibody or TCR), Antibodies, Assay Development, Benchmarking, Biology, Biotech and Pharmaceutical, Clinical Information Systems, Communication Skills, Computer Science, Data Modeling, Data Sets, Deep Learning, Environmental Sciences, GPU (Graphics Processing Unit), Human Resources, Immunology, Intellectual Property Development, Leadership, Machine Learning, Machine Tool, Medical Diagnosis, Model Validation, Modeling Languages, Office Equipment, Patents, Performance Testing, Predictive Modeling, Presentation/Verbal Skills, Publications, Python Programming/Scripting Language, Statistics, Technical Presentation, Technical Research, Training Data Sets, Training/Teaching, Writing Skills ## Description Adaptive Biotechnologies is seeking a Principal Machine Learning Scientist to lead the development of deep learning models for TCR-pMHC specificity prediction. In this role, you will leverage a large and growing proprietary dataset to design, train, and evaluate models that predict interactions between T cell receptors and peptide-MHC complexes. Your work will focus on developing new approaches that integrate sequence and structural information and rigorously testing their performance in practical settings. You will work closely with computational scientists, immunologists, and machine learning engineers across the organization. The team brings together expertise in immune biology, experimental assay development, and large-scale machine learning, with access to proprietary immune receptor datasets, shared GPU infrastructure, and engineering support for model development and training. This role sits at the intersection of modeling and experimental data generation. As model results highlight gaps in available data or suggest new experimental directions, newly generated datasets can provide additional signal for improving and validating the models. Models developed in this role contribute directly to diagnostic and therapeutic initiatives both within Adaptive and through external partnerships. This position offers the opportunity to advance predictive modeling of immune receptor specificity while seeing those advances translated into meaningful clinical and commercial applications. Key Responsibilities and Essential Functions * Design, implement, and train novel deep learning architectures for TCR-pMHC specificity prediction. * Extend and adapt advances in protein language models, structure prediction, generative modeling, and representation learning to the immune receptor setting. * Leverage and influence scalable training infrastructure to support large-scale model development and experimentation. * Lead rigorous benchmarking and evaluation strategies to ensure models are scientifically sound and practically superior. Define Modeling and Data Strategy * Translate biological principles of T cell recognition into principled modeling decisions. * Influence large-scale experimental data generation to maximize modeling leverage and long-term performance gains. * Evaluate emerging ML advances and determine when and how to incorporate them into Adaptive's modeling roadmap. * Shape the long-term technical direction of machine learning in immune receptor prediction across the organization. Drive Impact Across the Organization * Partner with computational biology, immunology, translational, and engineering teams to ensure models are capable, scalable, reproducible, and aligned with therapeutic and diagnostic goals. * Clearly communicate complex modeling insights to scientific leadership, executives, and external partners. * Contribute to intellectual property development and high-impact publications. ## Related Videos - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Photonic Computing: Programming a New Class of AI Accelerators (incl. Live Coding)](https://www.wearedevelopers.com/videos/100196-photonic-computing-programming-a-new-class-of-ai-accelerators-incl-live-coding) - [JavaScript? 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