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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Data Scientist - R&D Dsdh - Preclinical Sciences & Translational Safety - **Company:** Johnson & Johnson, S.a. - **Location:** Madrid, Spain - **Contract:** Permanent contract - **Skills:** 3d Models, Artificial Intelligence, Amazon S3, Cloud Computing, Cloud Database, Computational Biology, Information Engineering, R (Programming Language), Graph Database, Python (Programming Language), Machine Learning, SQL Databases, Management of Software Versions, Workflow Management Systems, Delivery Pipeline, Snowflake, Information Technology, Software Version Control, Data Pipelines, Serverless Computing, Amazon Redshift - **Published:** August 29, 2026 - **Apply:** https://www.jobleads.com/es/job/e9647a38643e47833a2be1ff5627ac6ee ## About the Role * Advanced degree (MS or PhD) in Data Science, Computational Biology, Toxicology, Pharmacology, Biomedical Engineering, Computer Science, or related field. * 3+ years of experience applying machine learning and/or data engineering to scientific or biomedical datasets. * Proficiency with Python and/or R, SQL, and modern data engineering tooling (cloud computing, workflow orchestration, version control). * Experience with ML model development, evaluation, and deployment pipelines. * Experience working with biological, toxicology, PK/PD, or in vivo datasets., * Experience in safety sciences, ADME/DMPK, toxicogenomics, or biomarker analytics. * Familiarity with scientific data formats (e.g., assay outputs, histopathology data, PK time-course datasets). * Exposure to ontologies, semantic technologies, or knowledge graph integration for scientific domains. * Experience with cloud-based data architectures (AWS S3, Snowflake, Redshift). * Understanding of regulatory data standards (e.g., SEND, CDISC). ## Description Johnson & J&J Innovative Medicine is recruiting for Principal Data Scientist - R&D DSDH - Preclinical Sciences & Translational Safety (PSTS). The primary location for this position is open to Spring House, PA; Titusville, NJ; Spring House, PA; Cambridge, MA; San Diego, CA; Beerse, Belgium; Madrid, Spain; or Barcelona, Spain., * Develop and deploy ML/AI models to support safety signal detection, dose selection, PK/PD modeling, toxicology insights, and translational interpretation. * Implement representation-learning, predictive modeling, and multivariate analytics for datasets spanning in vivo studies, in vitro assays, exposure-response data, and pathology information. * Partner with scientific SMEs to design modeling strategies aligned with PSTS decision points. * Apply model governance, versioning, and validation standards consistent with R&D AI practices. * Build and maintain scalable data pipelines that integrate PSTS-relevant data sources (e.g., toxicology studies, PK/PD datasets, biomarker readouts, animal study repositories). * Transform raw experimental outputs into standardized, analysis-ready, AI-ready datasets using Python, R, and cloud-native services. * Contribute to harmonized scientific data models in collaboration with data engineering and ontology teams. * Work directly with toxicology, DMPK, and safety stakeholders to interpret scientific context and translate study designs into computational requirements. * Apply understanding of mechanism-based toxicology, exposure-response concepts, and in vivo study structures to guide data transformations and modeling strategies. * Enhance cross-study comparability via standardized terminologies, metadata practices, and quality checks. * Collaborate with PSTS functional experts, R&D Data Science teams, and platform architects to ensure high-quality, scalable data solutions. ## Related Videos - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [How Cisco embraced a DevOps culture within its network engineering team](https://www.wearedevelopers.com/videos/99-how-cisco-embraced-a-devops-culture-within-its-network-engineering-team) - [WeAreDevelopers LIVE - CSS is DOOMed](https://www.wearedevelopers.com/videos/1838-wearedevelopers-live-css-is-doomed) - [TresJS a new declarative ThreeJS as Vue components](https://www.wearedevelopers.com/videos/543-tresjs-a-new-declarative-threejs-as-vue-components) - [Cross platform Augmented Reality development with React Native](https://www.wearedevelopers.com/videos/160-cross-platform-augmented-reality-development-with-react-native) - [Hate organising your photos? 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