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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Mechanistic Modeller - **Company:** Pharmaron - **Location:** Hoddesdon, UK - **Contract:** Permanent contract - **Skills:** Computer-Aided Design, Application Programming Interfaces (APIs), Artificial Intelligence, Data Analysis, R (Programming Language), Python (Programming Language), MATLAB, WinNonlin Software, Modeling and Simulation, Data Generation - **Published:** August 15, 2026 - **Apply:** https://www.totaljobs.com/job/modeller/pharmaron-job107846094 ## About the Role You are a scientifically curious and collaborative modeller with a strong grounding in pharmacokinetics, ADME and mechanistic modelling., * BSc in a relevant scientific discipline such as mathematics, engineering, bioscience, pharmaceutical sciences or a related subject MSc or PhD would be advantageous * Academic or industrial experience in pharmacokinetics, PBPK modelling, ADME, biopharmaceutics or related disciplines * Experience analysing and interpreting PK, ADME, biopharmaceutical or physicochemical datasets * Evidence of strong analytical and problem-solving skills * Experience working within multidisciplinary research teams * Experience using ADMET Predictor and/or other in silico tools would be desirable * Experience of large molecule drug discovery and the application of PK and PBPK concepts would be beneficial Technical expertise: * Understanding of PBPK modelling principles and applications * Familiarity with at least one commercial PBPK modelling software package, such as GastroPlus, Simcyp or PK-Sim * Understanding of IVIVE methodologies as applied to PK and/or biopharmaceutics extrapolation * Ability to interpret in vitro and in vivo DMPK datasets and apply them appropriately to modelling workflows * Understanding of drug absorption, distribution, metabolism and excretion and how these influence drug disposition and pharmacokinetic behaviour * Knowledge of physicochemical and API properties and their impact on ADME and biopharmaceutical performance * Understanding of non-compartmental and compartmental PK analysis, and knowledge of how these approaches can be applied to human dose predictions, would be advantageous * Experience using scientific programming and data analysis tools such as R, Python, MATLAB or Phoenix WinNonlin would be desirable * Knowledge of model-informed drug development principles would be beneficial What sets you apart * Strong scientific curiosity and a passion for applying modelling and simulation to real drug discovery challenges * Collaborative approach, with the ability to work effectively across functions, cultures and geographies * Excellent communicator, able to present complex modelling outputs clearly to internal teams and external partners * Detail-oriented and quality-focused, with strong data interpretation and documentation skills * Proactive problem solver who is keen to contribute to capability building and scientific innovation * Client-focused mindset with a commitment to delivering high-quality project outcomes * Interest in advancing Pharmaron's capability and reputation in PBPK and mechanistic modelling science ## Description Pharmaron is seeking a Mechanistic Modeller to support the application of modelling and simulation sciences across integrated drug discovery projects within our Integrated Drug Discovery Services group. This is an exciting role, ideal for a scientist with experience in pharmacokinetics, PBPK modelling, ADME, biopharmaceutics or related disciplines, who is motivated by applying mechanistic approaches to support data-driven decision making across drug discovery programmes. The Integrated Drug Discovery (IDD) Services group at Pharmaron is responsible for leading and delivering drug discovery projects for our client partners. The team comprises scientific expertise and strategic leadership across medicinal chemistry, CADD, biology, DMPK and translational science. Combined with Pharmaron's global research capabilities we design and deliver integrated programmes from target identification and hit finding through to IND filing. Working closely with our partners we define strategy, coordinate execution across teams and with an AI enabled Design-Make-Test-Analyse cycle support the progression of projects and innovative medicines towards the clinic. The opportunity You will support the development, qualification and application of PBPK and mechanistic models across modalities, helping to simulate drug disposition, pharmacokinetics and biopharmaceutical behaviour. Working closely with internal DMPK colleagues in the UK and China, as well as external client partners, you will help ensure appropriate data generation, interpretation, modelling and reporting to support continued project and contract delivery., * Support the development, qualification and application of PBPK models across modalities in support of Integrated Drug Discovery projects and other DMPK-related client contracts * Simulate drug disposition and biopharmaceutics behaviour to inform project strategy and decision making * Collate, review and interpret physicochemical, ADME, biopharmaceutical and pharmacokinetic datasets in preparation for PBPK modelling and other DMPK project activities * Work with DMPK scientists across the UK and China to generate appropriate data, including assay submissions, for modelling and project-related activities * Apply an understanding of drug physicochemical and API properties and their impact on ADME and biopharmaceutical behaviour * Use IVIVE principles to support pharmacokinetic and/or biopharmaceutics extrapolation * Identify, troubleshoot and resolve modelling challenges * Support human PK and dose predictions using routine empirical, non-compartmental or compartmental approaches, where appropriate * Present data and communicate results clearly to internal stakeholders and external partners * Document modelling activities in accordance with departmental procedures, quality standards and regulatory expectations * Contribute to the authorship of scientific reports for client projects * Support the development of internal PBPK capabilities and contribute to enhancing Pharmaron's scientific reputation in modelling and simulation science ## Related Videos - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Leveraging Large Language Models for Legacy Code Translation: Challenges and Solutions](https://www.wearedevelopers.com/videos/1157-leveraging-large-language-models-for-legacy-code-translation-challenges-and-solutions) - [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail) - [Enhancing AI-based Robotics with Simulation Workflows](https://www.wearedevelopers.com/videos/472-enhancing-ai-based-robotics-with-simulation-workflows) - [Augmented Intelligence for transport planning: Human in the Loop Modelling](https://www.wearedevelopers.com/videos/72-augmented-intelligence-for-transport-planning-human-in-the-loop-modelling) - [Building a hypercar from scratch](https://www.wearedevelopers.com/videos/607-building-a-hypercar-from-scratch) ## Related Articles - [Everything a Developer Needs to Know About MCP with Neo4j](https://www.wearedevelopers.com/magazine/604-everything-a-developer-needs-to-know-about-mcp-with-neo4j) - [UK Business Culture and Etiquette](https://www.wearedevelopers.com/magazine/326-uk-business-culture-and-etiquette) - [The Prompt Engineer ✍️](https://www.wearedevelopers.com/magazine/216-the-prompt-engineer) - [The Most Popular IT Jobs on the Market](https://www.wearedevelopers.com/magazine/376-the-most-popular-it-jobs-on-the-market) - [The Biggest German Tech Companies](https://www.wearedevelopers.com/magazine/424-the-biggest-german-tech-companies) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again)