> Markdown version of [/jobs/ext/2504221-scientist-i-discovery-dmpk](https://www.wearedevelopers.com/jobs/ext/2504221-scientist-i-discovery-dmpk). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md).

---

# Scientist I, Discovery DMPK

- **Company:** Arrowhead Pharmaceuticals
- **Location:** Madison, WI, United States
- **Experience:** Expert
- **Salary:** $88,000.0 - $100,000.0
- **Contract:** Permanent contract
- **Skills:** Microsoft Word, Microsoft Excel, Data Analysis, Microsoft Office
- **Published:** August 5, 2026
- **Apply:** https://www.indeed.com/viewjob?jk=c87a47cebdb25185

## About the Role

Arrowhead Pharmaceuticals is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics. As a member of the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team, you will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results. A successful candidate will demonstrate strong technical expertise in LC-MS, along with excellent problem-solving and communication abilities., * Bachelor of Science in Biology or related field and a minimum of 8 years of experience in cell biology, molecular biology, immunology, pharmacology, or a related field of biology (Or Master's degree and 5 years of experience)

 * Experience in protein LC/MS and related laboratory techniques
 * Demonstrated innovation, creativity and resilience in problem solving
 * Excellent oral and written communication skills
 * Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
 * Proficient with Microsoft Suite Applications (i.e. Excel, Word)
 * Demonstrated ability to learn and apply novel technologies

Preferred

 * Experience with high-resolution mass spectrometry, ideally applied to oligonucleotide therapeutics.
 * LC-MS method development or validation experience.

## Description

* Perform LC-MS based quantitative bioanalysis in biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
 * Support the identification of drug candidate metabolites.
 * Process, review, and interpret data independently.
 * Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
 * Understand experiment designs, generate figures to present data accordingly, and share bioanalysis results to cross-functional groups.
 * Set up and maintain lab instruments.
 * Maintain a well-documented laboratory notebook. Document experimental procedure and results accurately and meticulously.
 * Demonstrate sample analysis, troubleshooting and problem-solving skills.
 * Execute assays in a timely manner to meet deadlines.
 * Be able to address questions or concerns related to bioanalysis running conditions and data analysis criteria.
 * Adhere to safe laboratory practices.


## Related Videos

- [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery)
- [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail)
- [In-depth .NET Azure Functions: Isolated mode, performance and durable AI agents](https://www.wearedevelopers.com/videos/100207-in-depth-net-azure-functions-isolated-mode-performance-and-durable-ai-agents)
- [Developing the Rich Text Editor for DeepL.com](https://www.wearedevelopers.com/videos/1172-developing-the-rich-text-editor-for-deepl-com)
- [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture)
- [Data Science on Software Data](https://www.wearedevelopers.com/videos/162-data-science-on-software-data)

## Related Articles

- [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again)
- [Everything a Developer Needs to Know About MCP with Neo4j](https://www.wearedevelopers.com/magazine/604-everything-a-developer-needs-to-know-about-mcp-with-neo4j)
- [The Biggest German Tech Companies](https://www.wearedevelopers.com/magazine/424-the-biggest-german-tech-companies)
- [5 Future Technologies Coming in 2025](https://www.wearedevelopers.com/magazine/380-5-future-technologies-coming-in-2025)
- [Résumé-Driven Development: How IT trends affect the job market for software developers](https://www.wearedevelopers.com/magazine/59-resume-driven-development-how-it-trends-affect-the-job-market-for-software-developers)
- [Data Analyst Salary in the UK](https://www.wearedevelopers.com/magazine/278-data-analyst-salary-in-the-uk)