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# Sr Manager, Statistical Programming

- **Company:** Alnylam Pharmaceuticals, Inc.
- **Location:** Cambridge, MA, United States
- **Experience:** Expert
- **Salary:** $155,600.0 - $210,400.0
- **Contract:** Permanent contract
- **Skills:** Clinical Data Management, Computer Programming, Databases, Coherent Remote File System (CRFS), SAS (Software), SAS/STAT, SQL Databases, Statistics Packages
- **Published:** May 13, 2026
- **Apply:** https://jobs.localjobnetwork.com/job/detail/87150435/Sr-Manager-Statistical-Programming

## About the Role

* At least 8 years' industry (Pharmaceutical, Biotech, CRO) SAS programming experience or equivalent; At least 2 years management experience;
 * Knowledge of clinical trials and experience in using SAS to report the results of clinical trials and/or integrated analysis for submission;
 * Experience in constructing technical programming specifications and producing validated SAS programs
 * Strong experience in working with CDISC standards, including SDTM, and ADaM and define documentation;
 * Excellent knowledge of applied statistical methodologies;
 * Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT;
 * Good communications and organizational skills required;
 * Bachelor's Degree required, Master's Degree Preferred.

 * Clear alignment with Alnylam Core Values:
 + Commitment to People
 + Innovation and Discovery
 + Sense of Urgency
 + Open Culture
 + Passion for Excellence

## Description

The Senior Manager Statistical Programming will provide leadership and expert-level hands-on support to programmers. The senior manager may also guide the professional development of statistical programmers within the company.The position requires a broad, comprehensive and detailed understanding of statistical programming languages and software, industry best practices, clinical trial databases, regulatory filings, and pharmaceutical drug development., * Oversees the work of internal statistical programmers.Provides technical guidance and mentoring;

 * Provides timely support to study teams on all programming matters according to productstrategies;
 * Performs, plans and coordinates project work to ensure timely, quality delivery across multiple projects;
 * Contributes to strategic initiatives to improve departmental processes and scalability;
 * May function as lead programmer to produce or validate tables, listings, figures and analysis datasets;
 * Writes specifications to describe programming needs;
 * Creates and validates global macros or systems that streamline repetitive operations to increase programming efficiency;
 * Keeps abreast of current and new statistical programming techniques and other applicable technical advancements while assisting in their implementation;
 * Provides input into, or leads general standardization efforts (e.g., CRFs, query checks, standard statistical programs, data presentations);
 * Assists in developing programming processes consistent with industry best practices;

 * Reviews DMP, eCRF specs, and other clinical data management documents;

 * Reviews statistical analysis plans and other related documents;
 * Partners with or oversee CROs or Programming vendors to perform any of the above tasks;

 * Other duties as assigned.


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