> Markdown version of [/jobs/ext/2654782-dmpk-scientist](https://www.wearedevelopers.com/jobs/ext/2654782-dmpk-scientist). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # DMPK Scientist - **Company:** Actalent - **Location:** South San Francisco, CA, United States - **Salary:** $104,000.0 - $128,960.0 - **Contract:** Temporary to permanent - **Skills:** Data Analysis, PSN, Data Generation - **Published:** August 1, 2026 - **Apply:** https://dejobs.org/x/x/C85D3B27F57242DDBD9EB34CE8170F96/job/ ## About the Role * Hands-on experience in small molecule bioanalysis within a DMPK or related laboratory environment. * Strong background in bioanalysis, including tissue and plasma sample preparation and handling. * Proficiency with LC-MS/MS workflows for quantitative analysis of small molecules. * Demonstrated ability to prepare calibration curves and perform accurate dilutions for bioanalytical assays. * Experience with sample thawing, processing, and management in a regulated or process-driven laboratory setting. * Practical experience with pharmacokinetic and pharmacometric analysis tools such as NONMEM and PsN. * Ability to support the full DMPK workflow from sample preparation through data generation with limited supervision. * Capability to operate independently, take initiative, and manage multiple tasks in a fast-paced environment. * Strong documentation skills and attention to detail in recording experimental procedures and results. * Excellent collaboration and communication skills to work effectively within a small, cross-functional team. Additional Skills & Qualifications * Experience with plasma protein binding assays to characterize small molecule binding properties. * Experience with microsomal assays and other in vitro ADME studies. * Broader ADME and DMPK experience beyond core bioanalysis responsibilities. * PhD in a relevant scientific discipline (such as pharmacology, pharmaceutical sciences, chemistry, or a related field). * Postdoctoral experience in DMPK, bioanalysis, or a closely related area. * Familiarity with additional DMPK tools, software, and workflows is advantageous. * Interest in gaining comprehensive exposure to end-to-end DMPK workflows within a dynamic team environment. ## Description This role focuses on hands-on small molecule bioanalysis within a nimble drug metabolism and pharmacokinetics (DMPK) environment. The contractor supports end-to-end bioanalytical workflows, including tissue and plasma sample preparation, LC-MS/MS methods, and pharmacokinetic and pharmacometric analyses. The position suits someone who enjoys working at the bench, can quickly integrate into a collaborative team, and operates independently with minimal guidance while contributing across the full DMPK workflow., * Perform hands-on tissue and plasma sample preparation to support small molecule bioanalysis, ensuring accurate handling, labeling, and tracking of all samples. * Prepare and execute calibration curves and dilutions to support robust LC-MS/MS quantitation of small molecules. * Conduct sample thawing and processing activities in accordance with established bioanalytical protocols and quality standards. * Support and execute LC-MS/MS workflows for small molecule bioanalysis, including instrument setup, basic troubleshooting, and routine operation. * Contribute to pharmacokinetic and pharmacometric (PK/PD) analyses using tools such as NONMEM and PsN, supporting data analysis and interpretation. * Perform plasma protein binding assays and related in vitro studies as needed to support small molecule characterization. * Support microsomal and other in vitro ADME assays as required, contributing to broader DMPK and bioanalysis studies. * Work across the full DMPK workflow with limited handholding, taking ownership of assigned experiments and tasks from planning through execution and documentation. * Collaborate closely with a small, nimble DMPK team to prioritize tasks, troubleshoot issues, and ensure timely delivery of high-quality data. * Document experimental procedures, results, and observations clearly and accurately in laboratory records and reports. * Follow laboratory best practices, standard operating procedures, and safety guidelines while maintaining a clean and organized work area. * Contribute proactively to process improvements and workflow optimization within the DMPK and bioanalysis function., The role is based within a nimble DMPK team in a laboratory setting in South San Francisco. The environment is highly hands-on and collaborative, with a strong emphasis on flexibility and willingness to support multiple parts of the DMPK and bioanalysis workflow. You will work closely with a small group of scientists who value open communication, shared problem-solving, and direct contributions to project progress. The position offers the opportunity to gain extensive, practical experience across the full DMPK workflow, including sample preparation, LC-MS/MS operations, and data analysis. This is a one-year contract with potential for extension, providing a focused period to deepen technical skills and contribute meaningfully to small molecule bioanalysis in a fast-moving research setting. ## Related Videos - [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail) - [Enhancing AI-based Robotics with Simulation Workflows](https://www.wearedevelopers.com/videos/472-enhancing-ai-based-robotics-with-simulation-workflows) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [AI That Fits Your Business, Not the Other Way Around](https://www.wearedevelopers.com/videos/100148-ai-that-fits-your-business-not-the-other-way-around) - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [Data Science on Software Data](https://www.wearedevelopers.com/videos/162-data-science-on-software-data) ## Related Articles - [Everything a Developer Needs to Know About MCP with Neo4j](https://www.wearedevelopers.com/magazine/604-everything-a-developer-needs-to-know-about-mcp-with-neo4j) - [Data Analyst Salary in the UK](https://www.wearedevelopers.com/magazine/278-data-analyst-salary-in-the-uk) - [Data Analyst Salary Germany](https://www.wearedevelopers.com/magazine/277-data-analyst-salary-germany) - [The Biggest German Tech Companies](https://www.wearedevelopers.com/magazine/424-the-biggest-german-tech-companies) - [ Dev Digest 213: Petrol Prices, Agentic Workflows, AI Skills and CODE100!](https://www.wearedevelopers.com/magazine/718-dev-digest-213-petrol-prices-agentic-workflows-ai-skills-and-code100) - [Data Engineer Salary UK](https://www.wearedevelopers.com/magazine/253-data-engineer-salary-uk)