> Markdown version of [/jobs/ext/270617-machine-learning-senior-machine-learning-scientist-engineer](https://www.wearedevelopers.com/jobs/ext/270617-machine-learning-senior-machine-learning-scientist-engineer). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Machine Learning / Senior Machine Learning Scientist / Engineer - **Company:** Calico LLC - **Location:** South San Francisco, CA, United States - **Experience:** Expert - **Salary:** $170,000.0 - $233,000.0 - **Contract:** Permanent contract - **Skills:** Computational Biology, Data Infrastructure, Software Debugging, Python (Programming Language), Machine Learning, Tensorflow, Software Engineering, Pytorch, Deep Learning, Information Technology, Data Analytics - **Published:** May 29, 2026 - **Apply:** https://www.indeed.com/viewjob?jk=ee484ff5d4bd2791 ## About the Role Do you have experience in Structural modeling?, The ideal candidate should be familiar with state-of-the-art machine learning techniques, including language/sequence modeling, representation learning, generative models, and self-supervised learning techniques. Candidates should have experience implementing, extending, and debugging state of the art machine learning models, and have expertise in designing and building robust data infrastructure and tools. Candidates should be independent, self-motivated and be expected to explore relevant ML literature and apply novel approaches to various protein design problems at Calico. Candidates must demonstrate a strong ability to communicate ideas and results through publications and presentations and be able to work cross-functionally to execute on complex projects., * Ph.D. in Computer Science, Computational Biology, or related technical field; OR M.S. in Computer Science, Computational Biology, or related technical field, plus 2+ years industry experience * Experience in applying deep learning to model biological sequences and structures * Expert in TensorFlow, PyTorch, and/or JAX * Strong software engineering skills and substantial expertise in Python * Track record of outstanding communication and collaboration in a cross-functional environment * Strong analytical and quantitative skills * Must be willing to work onsite at least four days a week, * Domain expertise in computational biology, biochemistry or structural biology * Familiarity with state of the art structure modeling tools such as AlphaFold * Public recognition in the field, e.g. via scientific publications or success in machine learning competitions * Prior experience working with biologists * Prior experience working as an ML Engineer/Scientist ## Description Calico is seeking a machine learning research scientist to develop innovative machine learning algorithms to model and design proteins. This person will work with a team of dedicated experimental biologists to design experiments to test and iteratively refine machine learning predictions. ## Related Videos - [Getting Started with Machine Learning](https://www.wearedevelopers.com/videos/260-getting-started-with-machine-learning) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Photonic Computing: Programming a New Class of AI Accelerators (incl. Live Coding)](https://www.wearedevelopers.com/videos/100196-photonic-computing-programming-a-new-class-of-ai-accelerators-incl-live-coding) - [Machine learning in the browser with TensorFlowjs](https://www.wearedevelopers.com/videos/155-machine-learning-in-the-browser-with-tensorflowjs) - [30 Golden Rules of Deep Learning Performance](https://www.wearedevelopers.com/videos/11-30-golden-rules-of-deep-learning-performance) - [Graph Neural Networks: What’s behind the Hype?](https://www.wearedevelopers.com/videos/474-graph-neural-networks-what-s-behind-the-hype) ## Related Articles - [How to Become an AI Engineer](https://www.wearedevelopers.com/magazine/331-how-to-become-an-ai-engineer) - [What Are Large Language Models?](https://www.wearedevelopers.com/magazine/304-what-are-large-language-models) - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers) - [MLOps And AI Driven Development](https://www.wearedevelopers.com/magazine/82-mlops-and-ai-driven-development) - [Software Engineer Salary London](https://www.wearedevelopers.com/magazine/252-software-engineer-salary-london) - [MLOps – What’s the deal behind it?](https://www.wearedevelopers.com/magazine/125-mlops-what-s-the-deal-behind-it)