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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # MES / PAS-X MBR Designer - **Company:** Avcon, Inc. - **Location:** Durham, NC, United States - **Experience:** Expert - **Contract:** Permanent contract - **Skills:** Cyber Security, Data Integrity, GXP - **Published:** September 4, 2026 - **Apply:** https://www.careerjet.com/jobad/usb21767813dfd3e10519157ef66d063c6 ## About the Role * Demonstrable hands-on experience in PAS-X / MES MBR design within regulated pharmaceutical manufacturing. * Strong expertise in Master Batch Record authoring and configuration, including experience with PAS-X v3.4. * Experience with template-based MES design, reusable library elements, and fit-gap assessments. * Sound understanding of pharmaceutical manufacturing processes, GxP requirements, data integrity, and controlled documentation. * Ability to collaborate effectively with Business, Quality, Validation, and IT/OT stakeholders within established governance and project delivery frameworks. * Strong English communication and documentation skills. * Availability to work onsite in Durham, USA. * Authorization to work in the United States without employer sponsorship, now or in the future. Sponsorship is not available for this position. Preferred Experience * Previous experience with the Novartis Global MES Template and Novartis project delivery standards. ## Description We are seeking an experienced MES / PAS-X MBR Designer to support Master Batch Record development at a pharmaceutical manufacturing site in Durham. The role focuses on designing, configuring, and maintaining MBRs in PAS-X v3.4, aligned with the Global MES Template and site-specific manufacturing requirements., * Review and assess process documentation, batch records, manufacturing instructions, and other source materials required for MBR design. * Perform fit-gap assessments against the Global MES Template, global design standards, and approved library elements, identifying justified local adaptations. * Author, configure, update, and maintain MBRs in PAS-X v3.4 using approved templates, libraries, naming conventions, and design principles. * Incorporate product- and process-specific materials, quantities, parameters, instructions, calculations, checks, and in-process controls based on approved documentation. * Perform design quality, consistency, and system integrity checks and resolve issues before formal review and approval. * Support MBR review cycles, coordinate reviews, resolve comments, and incorporate approved feedback from Business, Quality, Validation, and IT/OT stakeholders. * Prepare and maintain design documentation, version histories, and traceability records. * Support design verification and deployment readiness through design reviews, dry runs, test preparation, and defect resolution. * Comply with applicable quality, GxP, data integrity, documentation, and information security requirements., Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health sys… + 1 month ago, Overview: Colliers Engineering & Design is seeking an Architecture Designer II to join our Cary, NC office! 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