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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Backend Engineer - **Company:** Orchestra Group LLC - **Location:** San Francisco, CA, United States - **Experience:** Expert - **Contract:** Permanent contract - **Skills:** Artificial Intelligence, Amazon Web Services, Microsoft Azure, Software as a Service, PostgreSQL, TypeScript, Unstructured Data, Cloud Platform System, ReactJS, Large Language Models, Prompt Engineering, Backend, Containerization, Machine Learning Operations, Front End Software Development, Api Design, NestJS - **Published:** September 4, 2026 - **Apply:** https://startup.jobs/senior-backend-engineer-orchestra-bio-8117912 ## About the Role * 6-8 years of backend development experience with production systems at scale * Deep expertise in Typescript, NestJS, PostgreSQL * Track record of building complex, scalable, reliable cloud-based software * Experience with cloud platform (AWS/Azure/GCP) and containerization * Strong experience in data modeling and API design * Collaborative mindset with proven track record of working effectively in small, fast-moving engineering teams Preferred * AI/ML integration with OpenAI, Anthropic, or similar LLM providers * Prompt engineering and RAG implementation experience * Full-stack capabilities - can contribute to frontend when needed (React/TypeScript) * Track record of mentoring other engineers ## Description We're seeking a Senior Backend Engineer to join our growing team in San Francisco. You'll work with our team to create complex but intuitive products to manage R&D. Challenges You'll Tackle Complex Decision Making: Build interactive tools that help organizations model different paths to market for their discoveries, assessing complex trade offs between time, money, and technical risk. Our users need to understand how decisions today affect their programs years into the future. Organizational Alignment: Create intuitive interfaces that help diverse teams (scientists, program managers, executives) understand how their work connects to broader company goals. This includes designing clear ways to visualize complex dependencies and communicate progress across teams. Scientific Operations: Design interfaces that scientists and researchers use daily to manage their studies, track progress, and coordinate with their teams. This requires crafting experiences that empower rather than get in the way of work. AI Powered R&D Management: Leverage LLMs to help teams generate and evaluate scenarios, infer scientific progress and risks from unstructured data, and surface critical insights from across their R&D portfolio. What Sets You Apart Complexity: You understand how to build backends for complex, interconnected systems where changes in one area cascade across multiple dimensions. You're excited about creating infrastructure that handles the unique challenges of long term, high stakes R&D programs. Agency: You're drawn to environments where you can shape both the technical architecture and product direction. You enjoy the responsibility of building foundational systems that will scale, balancing the speed needed at an early stage company with the craftsmanship required for complex, mission critical software. Curiosity: You're genuinely curious about how breakthrough products are developed and excited about building software that helps scientific organizations operate more effectively. You want your technical work to contribute to bringing medicines and other innovations to market. ## Related Videos - [Nest.js - TypeScript in the backend can also be clean](https://www.wearedevelopers.com/videos/1033-nest-js-typescript-in-the-backend-can-also-be-clean) - [Meet Your New BFF: Backend to Frontend without the Duct Tape](https://www.wearedevelopers.com/videos/682-meet-your-new-bff-backend-to-frontend-without-the-duct-tape) - [Watch Tests Go Brrrr! : Getting Started with Cypress in ReactJS](https://www.wearedevelopers.com/videos/282-watch-tests-go-brrrr-getting-started-with-cypress-in-reactjs) - [Developing the Backend with Stefan Lingler, CTO at Shpock](https://www.wearedevelopers.com/videos/100360-developing-the-backend-with-stefan-lingler-cto-at-shpock) - [Next, Nest, Nuxt… Nust?](https://www.wearedevelopers.com/videos/421-next-nest-nuxt-nust) - [Build and Deploy a Fullstack App with Open Source Tooling](https://www.wearedevelopers.com/videos/775-build-and-deploy-a-fullstack-app-with-open-source-tooling) ## Related Articles - [Dev Digest 120 - Apple and peers](https://www.wearedevelopers.com/magazine/455-dev-digest-120-apple-and-peers) - [Dev Digest 121 - AI goes offline](https://www.wearedevelopers.com/magazine/456-dev-digest-121-ai-goes-offline) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers) - [Dev Digest 132 - Binging WADFlix?](https://www.wearedevelopers.com/magazine/473-dev-digest-132-binging-wadflix) - [MLOps And AI Driven Development](https://www.wearedevelopers.com/magazine/82-mlops-and-ai-driven-development)