> Markdown version of [/jobs/ext/2713111-principal-information-system-engineer](https://www.wearedevelopers.com/jobs/ext/2713111-principal-information-system-engineer). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Information System Engineer - **Company:** Treeline, Inc. - **Location:** United States - **Experience:** Expert - **Salary:** $180,250.0 - $196,751.0 - **Contract:** Permanent contract - **Skills:** Microsoft Windows, Macintosh Computers, Information Systems, Databases, Multi-Factor Authentication, Identity and Access Management, Issue Tracking Systems, Information Technology Operations, Windows PowerShell, Azure Active Directory, Okta, Software Troubleshooting, Microsoft InTune, Information Technology, ManageEngine - **Published:** September 4, 2026 - **Apply:** https://startup.jobs/principal-information-system-engineer-treeline-biosciences-9790787 ## About the Role * Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience. * 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations. * A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds. * Strong hands-on experience with the following or similar: * Microsoft 365 Administration * Microsoft Intune * ManageEngine Endpoint Central * Microsoft Entra ID, including Conditional Access Policies * Okta * Endpoint security and device management * Multi-Factor Authentication (MFA) * PowerShell (Basic to Intermediate) * Strong troubleshooting, problem-solving, and analytical skills. * A track record of taking ownership in issue resolution. No problem is too big or too small. * Organized and detail orientated. * Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions. * Familiarity with ticketing systems and ITSM processes * Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently. * You are curious, creative, and innovative and want to continuously improve our processes. * Previous experience working in a biotech startup or biopharmaceutical. * Related certifications are a plus * Ability to explain technical issues clearly to non-technical users * Patient, customer-focused mindset with a commitment to service quality * Ability to prioritize tasks and manage multiple issues simultaneously This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states. ## Description * Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed. * Hands-on leadership for complex technical initiatives. * Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues. * Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions. * Manage modern workplace technologies and troubleshoot complex technical issues. * Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations. * Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data. * Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency. * Partner with in-house engineers and MSPs to support employees across multiple departments and countries. * Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes. * Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions., Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself: * Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline. * We do not conduct interviews through RingCentral, Skype or Telegram. * Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website. * You can find more information about job scams at consumer.ftc.gov/articles/job-scams. * To report job scams, head to ReportFraud.ftc.gov. ## Related Videos - [Recruitment Reinvented: Bold strategies and the $10K signing incentive](https://www.wearedevelopers.com/videos/1068-recruitment-reinvented-bold-strategies-and-the-10k-signing-incentive) - [Kubernetes and Microservices with Multi-Model Databases](https://www.wearedevelopers.com/videos/382-kubernetes-and-microservices-with-multi-model-databases) - [Fault Tolerance and Consistency at Scale: Harnessing the Power of Distributed SQL Databases](https://www.wearedevelopers.com/videos/1146-fault-tolerance-and-consistency-at-scale-harnessing-the-power-of-distributed-sql-databases) - [What makes Cybersecurity different for critical infrastructure?](https://www.wearedevelopers.com/videos/571-what-makes-cybersecurity-different-for-critical-infrastructure) - [Migrating half a million users to a new payment service provider](https://www.wearedevelopers.com/videos/730-migrating-half-a-million-users-to-a-new-payment-service-provider) - [Branch your database like your code: How schema changes and pull requests go hand in hand](https://www.wearedevelopers.com/videos/350-branch-your-database-like-your-code-how-schema-changes-and-pull-requests-go-hand-in-hand) ## Related Articles - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers) - [Top-Paying Tech Jobs (with Salaries)](https://www.wearedevelopers.com/magazine/372-top-paying-tech-jobs-with-salaries) - [Best Paying Jobs in Technology](https://www.wearedevelopers.com/magazine/256-best-paying-jobs-in-technology) - [How Much Does a Software Engineer Make? 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