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# Senior Principal Statistical Programmer (Remote)

- **Company:** WCG Clinical
- **Location:** Cary, NC, United States (Remote available)
- **Experience:** Expert
- **Salary:** $160,000.0
- **Contract:** Permanent contract
- **Skills:** Data Control, R (Programming Language), SAS (Software), System Testing, Data Management
- **Published:** September 4, 2026
- **Apply:** https://www.techcareers.com/job.asp?id=3377270632&tx=UT5046TYT&pt=1&aff=0B19D771-A501-4A5E-8338-2A822B784D54&utm_source=Job%20Feed&utm_medium=textkernel&utm_campaign=DE&utm_term=0B19D771-A501-4A5E-8338-2A822B784D54

## About the Role

EDUCATION REQUIREMENTS: Master's degree required. In limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered., * Minimum 8-10 years of statistical programming experience in a clinical trial environment.

 * Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
 * Proficiency in R programming is a must.
 * Demonstrated experience with CDISC standards and regulatory requirements.
 * Proven ability to independently lead complex programming efforts across studies.
 * Experience mentoring staff and driving technical standards or best practices.
 * Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.

TRAVEL REQUIREMENTS:

? 0% - 5%

? 5% - 10%

? 10% - 20%

? 20% - 50%

? >50%

## Description

The Senior Principal Statistical Programmer serves as a senior technical leader and subject matter expert in statistical programming, with deep expertise supporting clinical trials and Data Monitoring Committee (DMC) deliverables. This role combines advanced hands-on programming capabilities with technical leadership, driving the design, development, and standardization of high-quality statistical outputs. The Senior Principal Statistical Programmer independently leads complex programming initiatives, provides expert-level guidance across projects, and plays a key role in shaping programming standards, tools, and best practices. This role partners closely with biostatistics, project management, data management and cross-functional stakeholders to ensure high-quality, compliant, and efficient delivery of programming outputs.

ESSENTIAL DUTIES/RESPONSIBILITIES: To perform this job successfully, an individual must be able to perform each essential duty and responsibility satisfactorily. The accountabilities listed below are representative of the knowledge, skills, and/or ability required.

 * Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
 * Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
 * Lead the development, validation, and continuous improvement of DMC macros and programming standards.
 * Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
 * Drive the establishment and adoption of programming standards, best practices, and process improvements.
 * Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
 * Independently manage and prioritize programming activities across multiple studies or initiatives.
 * Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
 * Contribute technical expertise to proposals, project planning, and scope discussions as needed.
 * Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
 * Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
 * Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
 * Influence programming approaches, standards, and best practices across multiple studies or programs.
 * Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
 * Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
 * Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
 * Other duties as assigned by supervisor. These may, on occasion, be unrelated to the position described here.


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