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# Senior Scientist I, DMPK

- **Company:** Wave Life Sciences
- **Location:** Lexington, MA, United States
- **Experience:** Expert
- **Salary:** $157,000.0 - $213,000.0
- **Contract:** Permanent contract
- **Skills:** Software Tools, WinNonlin Software, Modeling and Simulation
- **Published:** September 15, 2026
- **Apply:** https://www.careerjet.com/job/us3e927dc3174ed8fd20ce6faf8a88de33/eaa

## About the Role

* Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or related discipline with at least 3 years of relevant experience, or M.S. with at least 6 years of industry experience
 * The ideal candidate will have experience supporting the development of RNA-based modalities (e.g., siRNA, antisense oligonucleotides, GalNAc conjugates, etc.), * Proficient in PK software tools such as Phoenix WinNonlin and conduct NCA
 * Conduct graphical analysis using standard tools like Phoenix WinNonlin, R, or similar
 * Demonstrate sound knowledge of PK/PD principles
 * Familiarity with regulatory requirements for nonclinical DMPK studies
 * Demonstrate expertise in plasma protein binding and in vitro DDI assessments (e.g., CYP inhibition/induction, transporter interactions)
 * Ability to innovate and think creatively to support the drug development process
 * Excellent communication, organizational, and teamwork skills
 * Knowledge and experience in bioanalysis to support DMPK studies (metabolite identification, biodistribution, etc.)
 * Hands-on experience with modeling and simulation is a plus

## Description

Wave Life Sciences is seeking a highly motivated and detail-oriented Scientist with strong expertise in bioanalytical and Drug Metabolism and Pharmacokinetics (DMPK) sciences to support drug development programs from preclinical through clinical stages. The successful candidate will play a key role in independently designing, executing, and interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in vitro drug-drug interaction (DDI) studies. This role will be based in our Lexington, MA office with a hybrid work arrangement., * Independently design, execute, and interpret in vitro and in vivo studies (i.e., ADME, PK, PK/PD) to support advancement of RNA therapeutic programs

 * Autonomously analyze and interpret PK, TK and PK/PD data using appropriate software tools (e.g., Phoenix WinNonlin), including conducting NCA and graphical exposure-response analyses
 * Represent DMPK function at cross-functional project team meetings
 * With guidance, plan, execute, and deliver DMPK deliverables from lead selection to IND stage
 * Collaborate with cross-functional teams including bioanalysis, discovery research, toxicology, clinical pharmacology, regulatory, and external CROs to meet program goals and timelines
 * Prepare high-quality scientific reports and integrate DMPK data into regulatory documents (IND, CTA, briefing documents, etc.)
 * Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data
 * Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings
 * Stay current with regulatory guidance and scientific advances in the field of bioanalysis and DMPK