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# Manager, Manufacturing Execution Systems (MES)

- **Company:** CareerCircle
- **Location:** Durham, NC, United States
- **Experience:** Expert
- **Salary:** $108,500.0
- **Contract:** Permanent contract
- **Skills:** Data Analysis, Information Systems, Data Integrity, Decision Support Systems, Technical Data Management Systems, Information Technology
- **Published:** September 15, 2026
- **Apply:** https://www.careercircle.com/jobs/all/all/usa/nc/durham/c45e3fde-97fb-4f96-bac9-43648f61497c

## About the Role

Auditing
Coaching
Operations
Leadership
Automation
Governance
Innovation
Communication
Data Analysis
Change Control
Data Integrity
Pharmaceuticals
FDA Regulations
Business Metrics
Biopharmaceuticals
Influencing Skills
Performance Metric
Talent Development
Information Systems
Lifecycle Management
Production Readiness
Relationship Building
Information Technology
Digital Transformation
Industrial Engineering
Manufacturing Operations
Electronics Manufacturing
Balancing (Ledger/Billing)
Data-Driven Decision Making
Good Manufacturing Practices
Pharmaceutical Manufacturing
Continuous Improvement Process
Key Performance Indicators (KPIs)
Troubleshooting (Problem Solving)
Manufacturing Execution System (MES)
Corrective And Preventive Action (CAPA), * Bachelor's degree in Biological Sciences, Engineering, Information Systems, Automation, or a related technical field.

 * Minimum eight years of experience in manufacturing systems, MES, automation, or regulated manufacturing environments.
 * Experience within the pharmaceutical or biopharmaceutical industry.
 * Strong knowledge of GMP, FDA regulations, electronic manufacturing systems, and data integrity principles.
 * Demonstrated success leading and developing technical or manufacturing-focused teams.
 * Proven ability to lead complex cross-functional projects within a matrix organization.
 * Excellent verbal and written communication skills with the ability to influence diverse stakeholders.
 * Strong collaboration and relationship-building skills across Manufacturing, Quality, MS&T, Engineering, IT, and Finance.

Desirable Requirements

 * Experience with MES roadmaps, manufacturing data analytics, KPIs, and digital manufacturing transformation initiatives.
 * Experience supporting validation, change control, CAPAs, audit readiness, and regulatory inspections for GMP computerized systems.

## Description

* Lead strategy, governance, and operational oversight for MES across the site.
 * Align MES priorities with manufacturing goals, project commitments, and production readiness requirements.
 * Oversee MES lifecycle management, including support, enhancements, upgrades, and system compliance.
 * Ensure manufacturing systems meet GMP, FDA, data integrity, and quality requirements.
 * Partner across Manufacturing, Quality, Engineering, and IT to resolve complex system challenges.
 * Drive continuous improvement using performance metrics, operational trends, and KPIs.
 * Support 24/7 manufacturing operations through effective MES troubleshooting and issue resolution.
 * Lead cross-functional projects, balancing resources and priorities to deliver business-critical initiatives.
 * Maintain audit-ready systems, documentation, procedures, and compliance practices.
 * Develop high-performing teams through coaching, talent development, and a culture of accountability., Auditing
Coaching
Operations
Leadership
Automation
Governance
Innovation
Communication
Data Analysis
Change Control
Data Integrity
Pharmaceuticals
FDA Regulations
Business Metrics
Biopharmaceuticals
Influencing Skills
Performance Metric
Talent Development
Information Systems
Lifecycle Management
Production Readiness
Relationship Building
Information Technology
Digital Transformation
Industrial Engineering
Manufacturing Operations
Electronics Manufacturing
Balancing (Ledger/Billing)
Data-Driven Decision Making
Good Manufacturing Practices
Pharmaceutical Manufacturing
Continuous Improvement Process
Key Performance Indicators (KPIs)
Troubleshooting (Problem Solving)
Manufacturing Execution System (MES)
Corrective And Preventive Action (CAPA)
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