> Markdown version of [/jobs/ext/2961142-manufacturing-execution-system-mes-site-lead](https://www.wearedevelopers.com/jobs/ext/2961142-manufacturing-execution-system-mes-site-lead). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Manufacturing Execution System (MES) Site Lead - **Company:** Merck Sharp & Dohme LLC - **Location:** San Francisco, CA, United States - **Experience:** Expert - **Salary:** $117,000.0 - $184,200.0 - **Contract:** Permanent contract - **Skills:** Data Analysis, Software Applications, Microsoft Office, Systems Development Life Cycle, Software Engineering, Real Time Systems, Data Management - **Published:** September 17, 2026 - **Apply:** https://dejobs.org/x/x/7AF5377B8B274A0DADD72AE74370B894/job/ ## About the Role Required * Bachelor of Science (BS) degree in a technical field (engineering or science) or equivalent. * Minimum of five (5) years' experience in Manufacturing Execution System (MES) * Ability to manage multiple priorities and know when to escalate for resolution. * Proven ability to work cross-functionally, delivering technical solutions to MES issues. * Strong problem-solving and troubleshooting skills. * Knowledge of regulatory/code requirements to USDA, European and International Codes, Standards and Practices. * Proficiency in Microsoft Office and job-related computer applications. * Report, standards, policy writing skills. Preferred * Experience in the application of Lean Six Sigma Methodology. * Pharmaceutical and Biotechnology manufacturing process experience. * Extensive knowledge of equipment and process validation. * Effective communication and interpersonal skills to interface effectively with all levels of colleagues in a team environment, and with external customers. * Customer-focused. * Self-motivated with a flexible approach. * Effective time management and multi-tasking skills. * Excellent attention to detail. * Strong data analysis capability. * Training skills. * Demonstrable analytical and systematic problem-solving skills. * Leadership qualities include focus on customers and patients, collaboration, acting with candor and courage, making rapid, disciplined decisions, driving results, building talent, and demonstrating ethics and integrity., Audit Management, Audit Management, Automation, Automation Systems, Business Process Improvements, Communication, Corporate Ethics, Customer-Focused, Data Analysis Tools, Data Management, Decision Making, Ethical Standards, Multitasking, Proactive Behavior, Problem Identification, Problem Management, Public Policy Writing, Quality Management, Real-Time Programming, Regulatory Compliance, Software Development Life Cycle (SDLC), Standards Compliance, Task Management, Team Communication, Vendor Management {+ 1 more} ## Description An opportunity has arisen for an MES (Manufacturing Execution System) Site Lead to join our team at the high-tech DeSoto site, within the Digital Records Design Hub. At our company, we aspire to be the premier research-intensive biopharmaceutical company. We're at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. Join us to use the power of leading-edge science to save and improve lives around the world., * Active participation in the Tier process and proactively resolving technical issues before they impact the business priorities. * Responsible and accountable for supporting MES related components of the process including on-floor support of manufacturing activities. * Active participation in the Tier process and proactively resolving technical issues before they impact the business priorities. * Developing and implementing optimal methodologies for the management of MES Systems Version 3.4 and future Versions, in compliance with company policies, quality regulations and industry norms. * Managing vendor performance and contracts * Supporting investigations by finding resolutions to MES problems * Supporting, maintaining, and developing MES recipes and capabilities * Collaborating with other technical functions to provide robust recipes and functionality that deliver reliable and sustainable performance. * Preparing and performing Update/Change Process and ensure they are raised and closed on time in compliance with required quality standards. * Providing expertise and technical knowledge to technical functions on MES * Performing MES administration and maintenance and ensure automation systems remain in a validated state. * Identify opportunities for continuous improvement. * Developing and update SOP's and conduct MES training. * Ensuring all documents must comply with SDLC (System Development Life Cycle) requirements. * Represent De Soto MES team within our Company global & corporate teams ## Related Videos - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [It's all about the Data](https://www.wearedevelopers.com/videos/425-it-s-all-about-the-data) - [Data Science in Retail](https://www.wearedevelopers.com/videos/586-data-science-in-retail) - [Model Based Systems Engineering in an Agile Product Development Process](https://www.wearedevelopers.com/videos/68-model-based-systems-engineering-in-an-agile-product-development-process) - [The Data Mesh as the end of the Datalake as we know it](https://www.wearedevelopers.com/videos/156-the-data-mesh-as-the-end-of-the-datalake-as-we-know-it) - [Data Science on Software Data](https://www.wearedevelopers.com/videos/162-data-science-on-software-data) ## Related Articles - [Best Companies to Work For in Germany: Top 25 Companies in 2023 ](https://www.wearedevelopers.com/magazine/33-best-companies-to-work-for-in-germany-top-25-companies-in-2023) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Best Companies to Work For in Berlin: Top 14 Companies in 2023 ](https://www.wearedevelopers.com/magazine/188-best-companies-to-work-for-in-berlin-top-14-companies-in-2023) - [Now is the time for industrialized software development](https://www.wearedevelopers.com/magazine/601-now-is-the-time-for-industrialized-software-development) - [From developer to manager – what does it take to become an engineering manager?](https://www.wearedevelopers.com/magazine/42-from-developer-to-manager-what-does-it-take-to-become-an-engineering-manager) - [Where To Find Software Engineering Jobs](https://www.wearedevelopers.com/magazine/396-where-to-find-software-engineering-jobs)