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# Senior Scientist, PBPK

- **Company:** Unitedkingdom
- **Location:** Kent, UK
- **Experience:** Expert
- **Salary:** £37,440.0
- **Contract:** Temporary to permanent
- **Skills:** Artificial Intelligence, R (Programming Language), Python (Programming Language), MATLAB, Mathematical Software
- **Published:** September 19, 2026
- **Apply:** https://www.apply4u.co.uk/jobs/senior-scientist-pbpk/47571302

## About the Role

reports, project team presentations, regulatory documents, and scientific publications.* As the Senior Scientist, PBPK, you will contribute to advancing modelling methodologies, automation, and integration of AI/ML-enabled predictive tools. **ROLE REQUIREMENTS** To be successful in your application to this exciting role as the Senior Scientist, we are looking to identify the following on your profile and past history: * A Degree or higher level in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or a related scientific discipline.* Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.* Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.* Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim, or similar platforms.* Evidence of proven ability to apply modelling solutions to pharmaceutical
development challenges.Key Words: Senior / Scientist / Biopharmaceutics / Modelling / Simulation / PBPK / PBBM / Pharmacokinetics / Regulatory / Drug Development / Modelling / Modeling / Drug Product / Mechanistic Modelling / Pharmacokinetics / Drug Discovery / Simcyp / GastroPlus / PK-Sim / Python / MATLAB / R Programming #J-18808-Ljbffr

## Description

duties and responsibilities are as follows:* As the Senior Scientist, PBPK, you will develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus, or equivalent software.* As the Senior Scientist, PBPK, you will support prediction and assessment of oral absorption, food effects, bioavailability, formulation bridging, dissolution, and particle size specifications, including virtual bioequivalence.* As the Senior Scientist, PBPK, you will perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to inform project decisions.* As the Senior Scientist, PBPK, you will collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and validation.* As the Senior Scientist, PBPK, you will support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.* As the Senior Scientist, PBPK, you will communicate modelling outcomes through technical


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