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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Staff Software Engineer - **Company:** LARA, BENITO MELENDEZ - **Location:** Menlo Park, United States - **Experience:** Expert - **Salary:** $195,900.0 - $293,900.0 - **Contract:** Permanent contract - **Skills:** .NET Framework, Application Programming Interfaces (APIs), Agile Methodology, Systems Engineering, C Sharp (Programming Language), Continuous Integration, DevOps, Firmware, Field-Programmable Gate Array (FPGA), Design of User Interfaces, Python (Programming Language), Linux System Administration, Software Architecture, Software Maintenance, Software Engineering, Software Systems, Systems Architecture, Systems Integration, Visual Systems, Technical Debt, Information Technology, Restful APIs - **Published:** September 19, 2026 - **Apply:** https://startup.jobs/senior-staff-engineer-software-4000-pacific-biosciences-sha-10115449 ## About the Role * Bachelor's degree in Computer Science, Engineering, or a related discipline * 10+ years of software engineering experience * Deep expertise in C#/.NET and proficiency in Python * Strong experience with real-time or embedded systems and hardware-software integration * Experience working with hardware systems such as robotics, optical systems, environmental sensors, or motion control * Strong proficiency with Linux environments * Solid understanding of software architecture, design principles, and best practices * Experience developing instrument control software, user interfaces, and system-level integrations * Experience designing and implementing APIs (e.g., RESTful services) * Demonstrated ability to independently drive complex technical projects from concept to production * Excellent interpersonal, written, and verbal communication skills Preferred Experience: * Experience developing scientific instrumentation * Master's degree or higher in a technical field * Experience working with firmware and low-level system interactions (e.g., FPGA interfaces) * Experience with Agile software development methodologies * Experience with DevOps practices, CI/CD pipelines, and automated testing frameworks * Experience in life sciences, biotech, medical devices, or other regulated environments Candidates must have current authorization to work in the United States without the need for present or future sponsorship. ## Description The Senior Staff Software Engineer is responsible for designing, developing, and delivering business-critical instrument control software for next-generation sequencing platforms. This is a highly visible, cross-functional role that works closely with mechanical, electrical, firmware, and systems engineering teams at PacBio. This role is ideal for a deeply technical engineer who thrives on solving complex system-level challenges and driving high-impact software solutions at the intersection of hardware and software., * Own and deliver business-critical instrument control software spanning multiple subsystems, directly impacting instrument performance, reliability, and customer experience * Drive technical design and implementation for complex, high-risk areas, independently defining approach and managing technical risk * Collaborate cross-functionally with mechanical, electrical, firmware, and systems teams to ensure robust hardware-software integration and clear requirements * Identify and resolve systemic issues in performance, reliability, and scalability, including proactively addressing technical debt * Lead design and code reviews while contributing hands-on development in C#/.NET, ensuring high-quality, maintainable software * Influence system architecture and technical direction, and mentor engineers to elevate team-wide engineering standards, To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications. ## Related Videos - [From DevOps to Scaled DevOps: How We’re Rebuilding Continuous Delivery as a Platform](https://www.wearedevelopers.com/videos/100018-from-devops-to-scaled-devops-how-we-re-rebuilding-continuous-delivery-as-a-platform) - [Playing Pong on a shoulder press machine](https://www.wearedevelopers.com/videos/100140-playing-pong-on-a-shoulder-press-machine) - [Rest API Antipatterns](https://www.wearedevelopers.com/videos/100208-rest-api-antipatterns) - [Robots are coming into the wild! Full-Stack Robotics Engineers, be ready!](https://www.wearedevelopers.com/videos/479-robots-are-coming-into-the-wild-full-stack-robotics-engineers-be-ready) - [REST In Peace: Why LLMs Can't CRUD](https://www.wearedevelopers.com/videos/100272-rest-in-peace-why-llms-can-t-crud) - [Agent Smith Gets Hardware: Autonomous IoT Hacking From Debug Port to Cloud API](https://www.wearedevelopers.com/videos/100258-agent-smith-gets-hardware-autonomous-iot-hacking-from-debug-port-to-cloud-api) ## Related Articles - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers) - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Software Engineer Salary London](https://www.wearedevelopers.com/magazine/252-software-engineer-salary-london) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [What is Software Engineering?](https://www.wearedevelopers.com/magazine/289-what-is-software-engineering) - [Where To Find Software Engineering Jobs](https://www.wearedevelopers.com/magazine/396-where-to-find-software-engineering-jobs)