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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Software Engineer II - Translational Genomics - **Company:** Broad Institute - **Location:** Cambridge, MA, United States - **Contract:** Permanent contract - **Skills:** JavaScript (Programming Language), Artificial Intelligence, Bash Shell, Big Data, Bioinformatics, Clinical Data Repository, Code Review, Databases, Continuous Integration, Extract Transform Load (ETL), Django Web Framework, Design of User Interfaces, Python (Programming Language), PostgreSQL, Cloudera, Software Engineering, Google Cloud, ReactJS, Build Server, Backend, Git, Front End Software Development, React Redux, Vertica, Terraform, Data Pipelines, Docker, Web Api - **Published:** September 26, 2026 - **Apply:** https://diversityjobs.com/main/sendform/8/8/28176/1/18444232?backUrl=%2Fcareer%2F18444232%2FSoftware-Engineer-Ii-Translational-Genomics-Massachusetts-Cambridge ## About the Role We value technical aptitude and willingness to learn just as highly as pre-existing domain knowledge. You should be able to work independently and solve engineering problems with minimal mentoring on the technical side. The genomic and clinical domain is complex and constantly changing - we're prepared to invest in a longer learning curve there. You don't need to arrive knowing genomics. You do need to arrive ready to build software independently and take ownership of your work., * Requires 2+ years of related experience with a Bachelor's degree in related discipline; or 1+ years and a Master's degree. Candidates with a PhD in a related field will also be considered. * Full-stack experience - comfortable across backend, database, and frontend layers. * Strong Python and Javascript skills. * Ability to work independently and manage your own time effectively. * Openness to AI-assisted development tools, with good judgment about responsible use around sensitive data. * Strong communication skills and comfort working with non-technical collaborators. * Curiosity and adaptability - willingness to learn new domains and technologies on the job. * Availability to be in the office at least twice per week. Preferred Qualifications * Experience with React.js, Redux, or similar frontend frameworks. * Experience with PostgreSQL, ClickHouse, or related databases. * Experience with data pipelines, ETL, or data-intensive applications. * Familiarity with Google Cloud Platform, Docker, Terraform, and Helm. * Experience with genomics, bioinformatics, or clinical data environments (HIPAA, PHI). * Experience with Hail or workflow orchestration tools. ## Description You will work across the full stack - cloud deployments, data pipelines, backend APIs, databases, and user interfaces. You'll start with well-scoped tasks guided by our lead software engineer, and progressively take on larger, more complex tasks and ownership of areas of the system as your capabilities grow., * Develop features across the full platform: data pipelines (Python/Hail), backend services (Python/Django), databases (PostgreSQL, ClickHouse), and frontend interfaces (React, Redux). * Assist with deployment related troubleshooting and maintenance. * Work independently on assigned tasks, growing in scope and complexity over time. * Collaborate with the lead software engineer on design and architecture, progressively taking on more scoping and design work as you gain experience. * Maintain and extend data pipelines that ingest genomic data, annotate variants, and load them into analytical databases. * Build and improve user interfaces that help researchers find disease-causing variants. * Understand the deployed environment well enough to assist with maintenance and troubleshooting when needed. * Write tests, participate in code review, and contribute to CI/CD workflows. * Collaborate with computational biologists, clinicians, and researchers to translate requirements into well-engineered solutions. Relevant Technologies * Python/Django * JavaScript/React.js/Redux * PostgreSQL * ClickHouse * Google Cloud Platform (Dataproc, GCS, Cloud Build) * Hail (genomic data processing framework) * Docker/Terraform/Helm * Bash/Unix/Linux environments * Git Experience with all technologies is not required. AI-assisted coding tools can be used where appropriate., This role is designed to grow with you. You'll start with well-defined tasks with guidance readily available, progressively take on larger areas of the system, and have a voice in where you focus - while maintaining breadth across the platform. The goal is for you to move toward a collaborative relationship with the lead engineer, influencing architecture and helping scope work over time. Team Environment The seqr team is small and highly productive. You will work closely with a lead software engineer and product owner who provides direction and design guidance - with the explicit goal of needing to do less of that over time. The team operates with clear technical leadership and shared accountability. The broader group works at the frontiers of genomic medicine. We value intellectual curiosity, creativity, and collaboration across disciplines. We expect our engineers to be open to adopting new tools and technologies - including AI-assisted coding - as they prove useful. The work is fast moving and loosely structured - we need teammates who are engaged in the mission, committed to quality engineering, and comfortable learning new domains. ## Related Videos - [How a Small Team Shrank a Microsoft Monorepo by 94%](https://www.wearedevelopers.com/videos/1236-how-a-small-team-shrank-a-microsoft-monorepo-by-94) - [Docker Compose: Rediscovered](https://www.wearedevelopers.com/videos/1978-docker-compose-rediscovered) - [Web APIs you might not know about](https://www.wearedevelopers.com/videos/281-web-apis-you-might-not-know-about) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Git for Code Reviews](https://www.wearedevelopers.com/videos/429-git-for-code-reviews) - [Shipping Faster with Less: Render on Cloud Hosting, AI Workloads, and the Future of DevOps](https://www.wearedevelopers.com/videos/1894-shipping-faster-with-less-render-on-cloud-hosting-ai-workloads-and-the-future-of-devops) ## Related Articles - [Highest Paying Tech Companies for Developers](https://www.wearedevelopers.com/magazine/220-highest-paying-tech-companies-for-developers) - [Data Engineer Salary UK](https://www.wearedevelopers.com/magazine/253-data-engineer-salary-uk) - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Dev Digest 121 - AI goes offline](https://www.wearedevelopers.com/magazine/456-dev-digest-121-ai-goes-offline) - [Software Engineer Salary London](https://www.wearedevelopers.com/magazine/252-software-engineer-salary-london) - [The Prompt Engineer ✍️](https://www.wearedevelopers.com/magazine/216-the-prompt-engineer)