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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # MES Technical Lead / Systems Architect LP2 - **Company:** Eli Lilly and Company - **Location:** Lebanon, IN, United States - **Experience:** Expert - **Salary:** $129,000.0 - $211,200.0 - **Contract:** Permanent contract - **Skills:** Application Layers, JIRA, Computer Engineering, Middleware, Github, IT Management, Message Queuing Telemetry Transport (MQTT), Software Architecture, Anypoint Studio, OPC Unified Architecture, SAP (Applications), System Testing, Systems Integration, Dataweave, GXP, Mulesoft, Servicenow - **Published:** September 10, 2026 - **Apply:** https://www.biospace.com/logon?PipelinedPage=%2Fjob%2F3073604%2Fmes-technical-lead-systems-architect-lp2%3FAction%3DContinueJobApplication%23application-form ## About the Role * Bachelor's degree in IT, Software/Computer Engineering or related field * 5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings * Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Additional Skills/Preferences * Modern software architecture and integration patterns * MuleSoft/Anypoint, DataWeave for MES-ERP(SAP)-PLM integrations * MQTT, Unified Namespace (UNS), OPC UA knowledge * CSV experience: Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+ * Understanding of eBRs, non-terminal record controls, e-signatures * Git/GitHub, GitHub Actions, MUnit, ALM/Jira * Familiarity with MABL and ServiceNow * Strong cross-functional communication and problem-solving skills Additional Information: * Position Location: Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required. * Travel Percentage (%): <10 * Shift Information: Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off-hour support may be required. ## Description Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end - from the Tulip application layer and Tulip Table data model, through MuleSoft integrations connecting SAP, QbDVision, and LabVantage, to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform's architecture and the hands-on engineer responsible for its ongoing design, build, and validation., * Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction * Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records * Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions) * Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11 * Guide components through validated migration lifecycle (DEV * QA * Production) * Participate in Change Control Board (CCB) and ServiceNow change management * Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA) * Mentor MES engineers; act as escalation point for complex issues * Collaborate with MES Product Owner on ALM requirements/backlog * Report system status and technical risk to site/IT leadership ## Related Videos - [Blueprints for Success: Steering a Global Data & AI Architecture](https://www.wearedevelopers.com/videos/1577-blueprints-for-success-steering-a-global-data-ai-architecture) - [Remote Driving on Plant Grounds with State-of-the-Art Cloud Technologies](https://www.wearedevelopers.com/videos/251-remote-driving-on-plant-grounds-with-state-of-the-art-cloud-technologies) - [Innovating Developer Tools with AI: Insights from GitHub Next](https://www.wearedevelopers.com/videos/1268-innovating-developer-tools-with-ai-insights-from-github-next) - [GitOps for the people](https://www.wearedevelopers.com/videos/461-gitops-for-the-people) - [Enabling intelligent logistics automation: home-grown Industrial IoT platform at Austrian Post](https://www.wearedevelopers.com/videos/2018-enabling-intelligent-logistics-automation-home-grown-industrial-iot-platform-at-austrian-post) - [Bringing AI Model Testing and Prompt Management to Your Codebase with GitHub Models](https://www.wearedevelopers.com/videos/1536-bringing-ai-model-testing-and-prompt-management-to-your-codebase-with-github-models) ## Related Articles - [How We Built a Worry-Free System That Runs for 10+ Years – And What We’d Do Again](https://www.wearedevelopers.com/magazine/751-how-we-built-a-worry-free-system-that-runs-for-10-years-and-what-we-d-do-again) - [Is Software Engineering Over-Saturated?](https://www.wearedevelopers.com/magazine/418-is-software-engineering-over-saturated) - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Best Companies to work for in London: Top 25 Companies in 2023](https://www.wearedevelopers.com/magazine/187-best-companies-to-work-for-in-london-top-25-companies-in-2023) - [The Most Popular IT Jobs on the Market](https://www.wearedevelopers.com/magazine/376-the-most-popular-it-jobs-on-the-market) - [7 Most Popular Web Developer Jobs in Europe](https://www.wearedevelopers.com/magazine/163-7-most-popular-web-developer-jobs-in-europe)