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# Backend Application Engineer

- **Company:** SOPHiA GENETICS
- **Location:** New Haven, CT, United States (Remote available)
- **Experience:** Expert
- **Salary:** $150,000.0 - $210,000.0
- **Contract:** Permanent contract
- **Skills:** Artificial Intelligence, Software as a Service, Cyber Security, Extract Transform Load (ETL), Data Stores, Distributed Systems, Python (Programming Language), Machine Learning, MongoDB, Commercial Software, Systems Development Life Cycle, Software Engineering, TypeScript, Web Services, Cloud Platform System, Large Language Models, Backend, Containerization, Deployment Automation, Devsecops, Static Application Security Testing, Golang, Microservices, Dynamic Application Security Testing
- **Published:** September 9, 2026
- **Apply:** https://www.builtincolorado.com/job/senior-backend-application-engineer/11066025?handler=ApplyRedirect

## About the Role

* 8+ years of experience in software engineering, with a focus on web services and ETL systems
 * Proven track record scaling high-volume, data-intensive systems
 * Expertise in distributed systems, microservices, and cloud architectures
 * Familiarity with containerization, orchestration, and CI/CD pipelines
 * High proficiency in our primary stack (TypeScript, Mongo, Go, Python) is not strictly required, but you should be familiar enough to be able to quickly spin up on languages applicable to your role.
 * Previous experience with commercial software products (SaaS and on-prem) that support 3rd party/external customers.
 * Experience working in early-stage technology (B2B SaaS) startups
 * Strong communication skills and the ability to work effectively in a collaborative environment

Bonus but not required:

 * Strong experience with MongoDB in particular and other data stores as well
 * Experience with or general familiarity with AI/ML, LLMs, & model tuning
 * Background or experience in infosec, red teaming, or broader cybersecurity concepts
 * Experience with other FOSS and Commercial SDLC security and DevSecOps tooling, including SCA, DAST, SAST, etc.

## Description

Manifest is hiring a highly qualified, Senior+ backend software engineer responsible for designing and scaling new and existing web services and ETL architecture to support hundreds of thousands of transactions per second. This role will drive high-performance, resilient system designs in a fast-paced, data-intensive environment.
The impact you will have:

 * Architect and build robust, fault-tolerant web and ETL services that scale to high throughput.
 * Act as a key communicator, bridging gaps between teams, clarifying technical concepts, and ensuring alignment across projects.
 * Identify and implement improvements in system performance and processes, ensuring the company remains competitive in a fast-paced market.
 * Design and build new features for the Manifest platform to be used by critical organizations around the world.

As a Senior Backend Engineer - Product & Platform:

 * Architect and implement scalable web services and ETL pipelines
 * Design high-performance systems that efficiently handle 10K's+ transactions/sec
 * Collaborate with engineering teams to optimize existing systems and integrate new technologies
 * Develop robust monitoring, testing, and deployment strategies for mission-critical services
 * Define and maintain the high standards of our engineering culture. As a part of a high performing engineering team, you'll help recruit and onboard your colleagues
 * Work closely with product management, designers, and other engineers
 * Resolve issues together quickly and collaboratively
 * Communicate internally and externally on what we're building and why it's special, Leads business development and strategic account growth with pharmaceutical and biotechnology partners across the U.S. West and Central regions. Responsibilities include acquiring customers, building pipelines in Salesforce, developing proposals, advancing precision medicine and genomics opportunities, negotiating and closing projects, and collaborating with scientific, commercial, and operational teams. The role focuses on NGS-based assays, biomarker discovery, clinical trial solutions, and companion diagnostics, with approximately 30% domestic and international travel.
Top Skills: Biomarker DiscoveryClinical Trial AssaysCompanion Diagnostics (Cdx)CtdnaGenomic AssaysLiquid BiopsyNext-Generation Sequencing (Ngs)SalesforceSophia Ddm
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