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# Principal / Senior Principal Software Engineer

- **Company:** Roche
- **Location:** Welwyn, UK
- **Experience:** Expert
- **Contract:** Permanent contract
- **Skills:** Clean Code Principles, Java (Programming Language), Artificial Intelligence, Amazon Web Services, Automation of Tests, Catalyst (Software), Cloud Engineering, Continuous Integration, Information Engineering, Data Files, Extract Transform Load (ETL), Dataspaces, Python (Programming Language), Machine Learning, NoSQL, Systems Development Life Cycle, Search Technologies, SQL Databases, Management of Software Versions, ReactJS, Backend, Agentic-AI, Vue.js, Event Driven Architecture, Build Management, Graphql, Front End Software Development, Microservices
- **Published:** October 6, 2026
- **Apply:** https://dejobs.org/x/x/B97E8618045444BC90BC881932199FED/job/

## About the Role

* Domain Expertise: Ph.D. or equivalent experience in the life science domain building full-stack software solutions, with a strong preference for drug discovery or pharmaceutical environments.
 * Full-Stack Engineering: Deep technical expertise across all stack layers, including backend (e.g., Python, Java) and modern frontend technologies (e.g., React, Vue).
 * Data Engineering & Cloud Architecture: Extensive experience in modern data engineering (ETL/ELT, SQL/NoSQL, REST & GraphQL APIs) and cloud-native deployments (preferably AWS).
 * SDLC & Engineering Excellence: Proven track record in establishing robust SDLC patterns, including versioning, automated testing, CI/CD, observability, and maintainable code bases.
 * Agentic & AI-Assisted Development: Demonstrated proficiency in adopting AI-assisted and agentic coding workflows individually and across teams.
 * Communication & Collaboration: Exceptional communication skills with the ability to articulate complex architectural concepts to technical and non-technical stakeholders alike.

## Description

The Computational Sciences Center of Excellence (CS CoE) is a strategic, unified group whose mission is to harness the power of data and Artificial Intelligence (AI) to assist scientists in delivering innovative, life-changing medicines to patients worldwide. Within the CS CoE, the Data and Digital Catalyst (DDC) organization leads the modernization of our computational ecosystems., * Interactive Tooling & Platforms: Design and build interactive tools for small and large molecule drug discovery, seamlessly integrating molecular design workflows, data, computational algorithms, and AI models.

 * Scalable Data Ecosystems: Build and enhance a modern, scalable ecosystem of applications and pipelines to acquire, capture, move, store, transform, link, share, and prepare scientific data for analysis.
 * Architectural Leadership: Leverage modern architecture patterns-such as microservices, event-driven architectures, and cloud-native frameworks (AWS)-to improve data workflows across key scientific domains.
 * AI & Agentic Engineering: Integrate diverse data sets to power Artificial Intelligence (AI), Machine Learning (ML), and Natural Language Search capabilities. Apply and champion modern AI-assisted and agentic coding practices within the engineering team.
 * Stakeholder & Scientific Collaboration: Partner directly with computational and research scientists to translate complex scientific challenges into high-performing, user-friendly technology solutions.
 * Technical Excellence & Mentorship: Provide technical leadership on ongoing strategic initiatives, define reusable architecture patterns, and mentor junior developers to uphold high engineering standards.

Who You Are

You are a passionate, collaborative full-stack engineering leader who thrives on solving complex scientific problems and driving software engineering best practices.