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# DMPK Scientist

- **Company:** Schrodinger, Inc.
- **Location:** Portland, OR, United States
- **Experience:** Expert
- **Salary:** $170,000.0 - $290,000.0
- **Contract:** Permanent contract
- **Skills:** Data Integration, MATLAB, Molecular Modeling, WinNonlin Software
- **Published:** October 15, 2026
- **Apply:** https://www.indeed.com/viewjob?jk=a4345211a2780650

## About the Role

* A DMPK analysis expert, who understands ADME principles and applications throughout drug development applications throughout drug discovery and development
 * A scientist with a robust background in DMPK who has specialized in the use and application of any of the following:

o In vitro/in vivo drug metabolism or transporter approaches to identify potential ADME liabilities and aid in compound optimization

o PK/PD and PBPK modeling approaches to optimize compound selection, dose optimization, and study design (this includes experience with commonly-used PK/PD software, such as Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology, or other equivalent software)

 * A proven Principal Investigator and scientific strategist who's self-driven and results-oriented
 * A highly motivated, self-driven, and results-oriented data-analyzer
 * An excellent communicator and presenter who can work both as a team player and a project driver
 * A flexible, curious scientist who's excited about networking and building internal and external relationships, * PhD in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least five years of experience working with DMPK in the pharmaceutical industry or Master's degree in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least ten years of experience working with DMPK in the pharmaceutical industry
 * Prior experience independently representing DMPK on project teams

## Description

* Develop and drive DMPK and PK/PD strategy for drug discovery projects
 * Represent the DMPK group on internal and intercompany project teams to help turn molecular modeling design ideas into druggable novel chemical entities
 * Collaborate with internal and intercompany project team members and external CROs to generate relevant data to enable knowledge and data integration
 * Analyze and integrate in silico ADME predictive solutions, physicochemical, ADME, and DMPK data to impact multiparameter optimization
 * Author and/or review appropriate reports for regulatory submission of development drug candidates and ensure the overall quality of the studies and interpretation (this entails supporting interactions with regulatory agencies)
 * Collaborate with scientific development team on establishment of predictive computational ADME/DMPK models