> Markdown version of [/jobs/ext/3954136-principal-software-engineer-instrument-simulations](https://www.wearedevelopers.com/jobs/ext/3954136-principal-software-engineer-instrument-simulations). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md).

---

# Principal Software Engineer, Instrument Simulations

- **Company:** Lila Sciences, Inc.
- **Location:** Cambridge, MA, United States
- **Experience:** Expert
- **Salary:** $204,000.0 - $272,000.0
- **Contract:** Permanent contract
- **Skills:** Java (Programming Language), Application Programming Interfaces (APIs), Artificial Intelligence, C++ (Programming Language), Code Review, Continuous Integration, Monitoring of Systems, Python (Programming Language), Robotic Automation Software, Software Engineering, Systems Integration, Agentic-AI, Information Technology
- **Published:** October 27, 2026
- **Apply:** https://www.careerbuilder.com/job-details/principal-software-engineer-instrument-simulations-cambridge-ma--c9c47b41-d9c5-4d56-93e9-e7698bd35171

## About the Role

Software Engineering, Software Engineering, Laboratory Automation, Simulation, Experiment Design, Artificial Intelligence (AI), Instrumentation, Automation, Artificial Intelligence (AI) Agents, Application Programming Interface (API), * Bachelor's or Master's degree in Computer Science, Engineering, or a related field: Background that supports technical and leadership capabilities.

 * 10+ years of software development experience, including 5+ years in a leadership role: Demonstrates ability to lead and manage complex projects and engineering teams.
 * Proven experience in architecting and directing large-scale software projects: Skilled in designing and leading the development of scalable, reliable, and maintainable systems.
 * Strong proficiency in programming languages such as C++, Python, or Java: Capable of setting technical standards and guiding development practices.
 * Strong record of implementing and advocating for engineering best practices such as code reviews, testing, and continuous integration.
 * Experience in leading diverse engineering teams with a focus on collaboration, innovation, and efficiency.
 * Excellent strategic thinking skills, with the ability to understand and align team efforts with organizational goals.
 * Proven ability to mentor and develop engineering talent, fostering an environment of growth and continuous learning.
 * Outstanding communication and interpersonal skills: Effectively engage with stakeholders at all levels, from developers to senior executives.

Bonus Points For

 * Ph.D. in Computer Science, Engineering, or a related field
 * Experience in leading the development of laboratory automation systems or scientific instrumentation
 * Experience with organizational change management and fostering innovation in large technical programs.
 * Track record of successful project delivery in agile environments, optimizing team workflows and balancing priorities.
 * Published work or presentations that highlight contributions to the field of software engineering and leadership in simulation or automation systems.

## Description

Lila Sciences is seeking a Principal Software Engineer, Instrument Simulations to architect and lead the development of our next-generation laboratory automation platform. In this role, you'll be responsible for designing the simulation infrastructure and integration layer that connects AI-driven experimental design with physical robotic systems, enabling closed-loop scientific discovery at unprecedented scale.

What You'll Be Building

 * Architect and implement high-fidelity simulation environments that model complex laboratory instrumentation, fluidics, and robotic workflows
 * Design robust integration patterns between heterogeneous hardware systems, ensuring reliable and safe execution of fully automated experiments
 * Lead the development of APIs and interfaces that enable scientists and AI agents to seamlessly interact with sophisticated automation infrastructure
 * Maintain and help establish best practices for hardware-software integration, system monitoring, and CI/CD in laboratory automation contexts for all newly developed systems
 * Mentor engineers, likely leading a small agile team