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# Principal Programmer

- **Company:** Glaxosmithkline PLC
- **Location:** Durham, NC, United States
- **Experience:** Expert
- **Salary:** $126,225.0 - $210,375.0
- **Contract:** Permanent contract
- **Skills:** Clean Code Principles, Agile Methodology, Artificial Intelligence, Data Analysis, Computer Programming, Information Engineering, R (Programming Language), Python (Programming Language), Machine Learning, SAS (Software), Programming Languages
- **Published:** October 27, 2026
- **Apply:** https://gsk.wd5.myworkdayjobs.com/GSKCareers/job/USA---Pennsylvania---Upper-Providence/Principal-Programmer_450438-1

## About the Role

We are looking for professionals with these required skills to achieve our goals:

 * 5+ years of programming experience within the pharmaceutical, biotechnology, healthcare, or other regulated industry.
 * Experience programming in one or more languages such as SAS, R, Python, or a comparable programming language.
 * Experience supporting clinical trials, clinical development programs, or analysis of clinical research data.
 * Experience developing, validating, and maintaining custom programs, analyses, tables, figures, or listings.
 * Experience applying programming standards, quality control procedures, and regulatory requirements within a regulated environment.
 * Expertise in Oncology therapeutic area specific requirements like RECIST1.1.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

 * Experience collaborating with cross-functional stakeholders to deliver programming or data analysis solutions.
 * Experience guiding others in the use of Artificial Intelligence/Machine Learning (AI/ML) tools or applying these tools to improve efficiency
 * Experience contributing to internal technical discussions, forums, or external technical organizations
 * Experience contributing to department strategies and key technical initiatives through working groups or sub-teams
 * Demonstrated networking and collaboration across departments, divisions, and external partners
 * Experience facilitating integration across matrix teams and contributing to planning and execution of programming activities
 * Experience guiding teams and individuals, fostering continuous improvement, collaboration, and innovation
 * Expertise in Oncology therapeutic area specific requirements like RECIST1.1.
 * Strong expertise in CDISC standards and its application
 * Demonstrated proficiency in R.

#LI-GSK #AGTech

Skills
Agile Leadership, Agile Methodology, Clinical Development, Data Engineering, Data Science, Influencing Without Authority, Learning Agility, Problem Solving, Statistical Programming

 * If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $126,225 to $210,375. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

## Description

We are seeking a Principal Programmer to join our Clinical Programming team, contributing to pipeline delivery across complex and pivotal studies. This role operates within an agile, squad-based environment, where you will lead study delivery, collaborate with cross-functional teams, and act as a technical mentor to ensure high-quality and timely outputs. Working closely with stakeholders across clinical, statistical, and operational functions, you will play a key role in bridging scientific requirements with technical solutions, supporting the successful execution of clinical development programmes within a global setting., * Independently lead programming activities for one or more studies, ensuring development, maintenance, and validation of complex analysis packages

 * Foster quality assurance by ensuring programming activities adhere to standards such as Good Programming Practices and CDISC standards.
 * Mentor junior programmers by providing guidance and support in technical programming tasks and industry best practices
 * Lead programming support for regulatory interactions (e.g., EMA, FDA)
 * Identify gaps and inefficiencies and recommend and implement innovative solutions aligned with standards and best practices
 * Establish and uphold governance frameworks, identify risks early and devise mitigation plans, ensuring timely escalation