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# Method Development Lead

- **Company:** Nexus
- **Location:** UK
- **Experience:** Expert
- **Salary:** £60,000.0
- **Contract:** Permanent contract
- **Skills:** Data Systems, Lynx, Minitab, GXP
- **Published:** October 2, 2026
- **Apply:** https://www.collegerecruiter.com/job/2915884205-method-development-lead

## About the Role

* Degree in Biochemistry, Biomedical Science, or related field., * 4+ years in a GxP laboratory (2+ years in management).
 * Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
 * Proficiency in method development, optimisation, and validation.
 * Strong problem-solving and troubleshooting capabilities.
 * Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
 * Understanding of regulatory and GLP requirements.
 * Strong communication, organisational, and leadership skills.

Preferred Skills

 * Experience with Design of Experiments (DOE) for method optimisation.
 * Proficiency in Minitab/statistical software.
 * Experience with Empower and Mass Lynx data systems.
 * GC experience and familiarity with regulatory inspections.

## Description

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards., * Key duties include:

 * Leading method development and validation as a subject matter expert.
 * Optimising analytical extraction techniques, chromatography methods, and LC columns.
 * Managing and mentoring the Method Development & Validation team.
 * Ensuring compliance with GLP, SOPs, and international guidelines.
 * Troubleshooting analytical methods and recommending improvements.
 * Overseeing cost-effective laboratory operations and consumable spend.
 * Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
 * Supporting regulatory submissions and resolving regulatory queries.
 * Conducting investigations, implementing CAPAs, and driving continuous improvement.
 * Preparing, reviewing, and ensuring adherence to GLP SOPs.
 * Leading team meetings and staff development sessions.