> Markdown version of [/jobs/ext/4163825-technical-lead-medicines-safety-technologies-78-230-87-809-p-a-benefits](https://www.wearedevelopers.com/jobs/ext/4163825-technical-lead-medicines-safety-technologies-78-230-87-809-p-a-benefits). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Technical Lead, Medicines Safety Technologies - £78,230 - £87,809 p.a. + benefits - **Company:** Medicines and Healthcare Products Regulatory Agency - **Location:** London, UK (Remote available) - **Experience:** Expert - **Salary:** £22,663 - £78,230 - **Contract:** Temporary to permanent - **Skills:** Artificial Intelligence, Bioinformatics, Computational Biology, Databases, Machine Learning, Data Analytics - **Published:** October 21, 2026 - **Apply:** https://www.indeed.com/viewjob?jk=8d615e582d8acc0f ## About the Role * Significant experience and recognised expertise in at least one of the following areas, + Pre-clinical assessment, toxicology and New Approach Methodologies (NAMs) + Artificial Intelligence and Machine Learning + Healthcare data science and computational modelling + Pharmacology, drug discovery or development + or related scientific areas. * Experience applying scientific and technical expertise to complex regulatory, healthcare, research or industry challenges; and evaluating scientific evidence and translating findings into practical recommendations and actions. * Experience working with multidisciplinary teams involving scientific, technical and non-technical stakeholders, and engaging effectively with external stakeholders, including academia, industry and research organisations. * Experience preparing technical reports, scientific assessments, briefings, publications or regulatory submissions., * Communicating and Influencing * Working Together * Delivering at Pace Technical skills We'll assess you against these technical skills during the selection process: * Degree in a relevant scientific, technical or healthcare discipline (or equivalent experience). * Postgraduate qualification (MSc, PhD or equivalent experience) in a relevant field such as artificial intelligence, computational biology, pharmacology, toxicology, data science, bioinformatics, pharmaceutical sciences or a related discipline. * Recognised technical expertise in either: Pharmacology, Toxicology, Drug Development, Safety Science, New Approach Methodologies (NAMs) or related disciplines, OR AI, Machine Learning, Healthcare Data Science, or related disciplines * Ability to critically evaluate scientific evidence, AI methodologies, model performance and validation approaches. * Strong analytical skills and the ability to interpret complex scientific, technical and data-driven information. * Excellent written and verbal communication skills, including the ability to communicate highly technical concepts to diverse audiences. We only ask for evidence of these technical skills on your application form: * Recognised technical expertise in either: Pharmacology, Toxicology, Drug Development, Safety Science, New Approach Methodologies (NAMs) or related disciplines, OR AI, Machine Learning, Healthcare Data Science, or related disciplines, Successful candidates must undergo a basic (or equivalent) criminal record check. People working with government assets must complete baseline personnel security standard (opens in new window) checks. ## Description We are currently looking for a Technical Lead, Medicines Safety Technologies to join our Benefit Risk Evaluation I Function within the Safety & Surveillance Group. This is a full-time opportunity, on a permanent basis. The role will be based in 10 South Colonnade, Canary Wharf London, E14 4PU. Government departments and agencies are working towards implementing a minimum 60% attendance in office sites. We are currently implementing a flexible, hybrid way of working, with a minimum of 8 days per month working on site to enable the collaboration and contact with partners and stakeholders needed to deliver MHRA business. Attendance on site is driven by business needs so depending on the nature of the role, this can flex up to 12 days a month, with the remainder of time worked either remotely or in the office. Some roles will need to be on site more regularly. Remote working is potentially available for some specific roles. Please discuss this with the recruiting manager before accepting an appointment. The Safety and Surveillance (S&S) Group brings together into a single integrated structure expertise on the safety of all medical products with enforcement capabilities. These functions are supported by the Agency’s data and evidence generating capabilities, complementing our signal generating abilities. Against this background and the drive to improve treatment availability for patients, safety remains at the heart of all our decision making across the product life cycle. The central mission of the Safety & Surveillance portfolio is to protect the public by appropriately identifying, assessing and managing the risks associated with medical products. In every aspect of this work, we harness the best science, technology, information and professional practice to protect patients in new and impactful ways. The core purpose of Benefit Risk Evaluation is to deliver a robust assessment of potential safety signals using data from a range of sources along with technical, scientific, clinical and regulatory knowledge, and practical experience. The team conducts benefit-risk evaluations for medicines and medical device across a broad spectrum of therapeutic areas to guide actions that protect patient safety. The team is responsible for: * Signal detection of emerging safety issues * Evaluating the benefit risk of signals and developing effective and measurable risk mitigation measures * Using data and embracing new technologies to develop the evidence to support our actions and understand their impact, This is an exciting opportunity to play a senior technical leadership role in the MHRA's pioneering regulatory sandbox, “Beyond ADMET: AI for Medicines Safety”, an innovative initiative exploring how artificial intelligence can transform medicines development and strengthen patient safety. Working alongside the Head, AI for Medicines Safety, you will provide specialist scientific and technical leadership, helping to shape the evidence, methodologies and innovations that inform future regulatory approaches. This is a unique opportunity to work at the intersection of AI, toxicology, pharmacology, medicines development and regulatory science while contributing to the MHRA's wider ambitions for AI-enabled innovation and patient safety., * Provide senior scientific and technical leadership for the “Beyond ADMET: AI for Medicines Safety” Sandbox programme, ensuring programme activities are scientifically robust, technically credible and aligned with regulatory objectives. * Work in partnership with the Head, AI for Medicines Safety to ensure the programme benefits from complementary expertise across artificial intelligence, healthcare data science, toxicology, pharmacology, medicines development and regulatory science. * Lead the evaluation of emerging methodologies, technologies, datasets and evidence relevant to AI-enabled medicines development, safety assessment and regulatory decision-making. * Build and maintain strong relationships with experts across the MHRA, industry, academia and government, representing the programme through technical engagement, collaboration and thought leadership activities., * Anonymised CV which sets out your career history, previous experience and skills, highlighting specific responsibilities that are relevant for this role. * Online application form, including questions based on the Behaviour, Experience and Technical Success Profiles. Please ensure all application questions are completed in full; your application may not be considered if any responses are left blank. The panel will look at your application and are looking for evidence of the stated points. We may raise the benchmark score required if we receive a high number of applications. 2. Main Panel Interview Successful candidates from the sift stage will be invited to attend an interview. We use a blended interview technique, allowing us to find out more about you. We use the Success Profile framework and at interview we will be assessing Behaviours and Experience. Your interview will include: * Presentation, to be prepared as part of your interview, with further information being supplied when you reach this stage. At interview, we will be asking questions relating to the following: * Behaviours, as listed in the person specification * Experience, as listed in the person specification * Strengths The panel will look at your application and are looking for evidence of the stated points. We may raise the benchmark score required if we receive a high number of applications. If you require any disability related adjustments at any point during the process, please contact careers@mhra.gov.uk as soon as possible. Candidates will be subject to UK immigration requirements as well as Civil Service nationality rules. Further information on whether you are able to apply is available here. Successful candidates must pass a disclosure and barring security check as well as animal rights and pro-life activism checks. People working with government assets must complete basic personnel security standard checks. Certain roles within the MHRA will require post holders to have vaccinations, and in some circumstances, routine health surveillance. These roles include: * Laboratory-based roles working directly with known pathogens * Maintenance roles, particularly those required to work in laboratory settings * Roles that involve visiting other establishments where vaccination is required * Roles required to travel overseas where specific vaccination may be required. Applicants who are successful at interview will be, as part of pre-employment screening subject to a check on the Internal Fraud Database (IFD). This check will provide information about employees who have been dismissed for fraud or dishonesty offences. This check also applies to employees who resign or otherwise leave before being dismissed for fraud or dishonesty had their employment continued. Any applicant’s details held on the IFD will be refused employment. A candidate is not eligible to apply for a role within the Civil Service if the application is made within a 5 year period following a dismissal for carrying out internal fraud against government. Any move to the MHRA from another employer will mean you can no longer access childcare vouchers. This includes moves between government departments. You may however be eligible for other government schemes, including Tax-Free Childcare. Determine your eligibility here. Individuals appointed on level transfer will retain their existing salary and are responsible for ensuring they fully understand the financial implications of any potential move and the impact (if any) on their terms. If an individual is in any doubt, they should seek clarification before accepting a job offer. Staff joining on promotion will receive up to a 10% increase of their current basic salary, or the pay band minimum, whichever is the greater. The individual will not retain any allowances paid by the former department/Agency, unless there are special circumstances, such as a reserved right to those allowances on transfer. Successful candidates may be subject to annual Occupational Health reviews dependent on role requirements. If you have any queries, please contact careers@mhra.gov.uk. Feedback will only be provided if you attend an interview or assessment., * UK nationals * nationals of the Republic of Ireland * nationals of Commonwealth countries who have the right to work in the UK * nationals of the EU, Switzerland, Norway, Iceland or Liechtenstein and family members of those nationalities with settled or pre-settled status under the European Union Settlement Scheme (EUSS) * nationals of the EU, Switzerland, Norway, Iceland or Liechtenstein and family members of those nationalities who have made a valid application for settled or pre-settled status under the European Union Settlement Scheme (EUSS) * individuals with limited leave to remain or indefinite leave to remain who were eligible to apply for EUSS on or before 31 December 2020 * Turkish nationals, and certain family members of Turkish nationals, who have accrued the right to work in the Civil Service