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# Director, Epidemiology & Methodological Innovation Organization

- **Company:** Tempus Inc
- **Location:** Chicago, IL, United States (Remote available)
- **Experience:** Experienced
- **Salary:** $170,000.0 - $230,000.0
- **Contract:** Permanent contract
- **Skills:** Artificial Intelligence, Clinical Data Repository, Cyber Security, Databases, Data Files, Data Security, Database Analysis, R (Programming Language), Machine Learning, SAS (Software), Electronic Medical Records, GXP
- **Published:** October 5, 2026
- **Apply:** https://www.careerbuilder.com/job-details/director-epidemiology-methodological-innovation-chicago-il--b94ec57c-d4b2-4745-8089-3f743f9f7d46

## About the Role

* Education: PhD (preferred) or PharmD in Epidemiology, Biostatistics, Health Economics, or a related quantitative field.
 * Experience: 7+ years in HEOR/RWE, with at least 3 years in a leadership capacity.
 * Deep expertise in oncology is required.
 * Methodological Mastery: Proven track record of developing or implementing advanced methods (e.g., target trial emulation, propensity score applications in complex cohorts, or machine learning-augmented epidemiology).
 * Technical Proficiency: Advanced skills in R or SAS. Experience working with "messy" real-world data (EHR, claims, and/or genomic data) is essential.
 * The "Consultant" Mindset: Exceptional ability to walk into a room of biopharma executives and simplify complex methodological hurdles into a clear strategic roadmap.
 * Leadership: Demonstrated experience mentoring junior scientists and leading cross-functional squads in a fast-paced, high-growth environment., Alliance/Partner Management, Artificial Intelligence (AI), Biomarkers, Biostatistics, Business Development, Clinical Data, Clinical Medicine, Conferences, Consulting, Cross-Functional, Customer Relations, Data Science, Data Sets, Database Analysis, Disease, Drug Development, Ecosystems, Epidemiology, GEP (Good Engineering Practices), Genomics, HIPAA (Health Insurance Portability and Accountability Act), Health Economics, Healthcare, Information/Data Security (InfoSec), Intellectual Property (IP), Leadership, Machine Learning, Medical Record System, Medicine, Mentoring, Patient Care, Project/Program Management, Publications, R Programming Language, Regulations, Research Protocols, Thought Leadership

## Description

* Methodological Innovation: Lead the development of novel approaches for RWE, including the use of external control arms (ECA), causal inference in high-dimensional data, and the integration of longitudinal clinical data with molecular/genomic signatures.
 * Research Design & Implementation: Oversee the end-to-end execution of retrospective database analyses. You will act as the primary architect for study protocols, ensuring they push the boundaries of current HEOR/RWE standards while maintaining scientific rigor.
 * Scientific Thought Leadership: Serve as a subject matter expert for biopharma clients, advising them on "first-in-kind" study designs. You are expected to contribute to the broader scientific community through high-impact publications and presentations at conferences like ISPOR, ISPE, and ASCO.
 * Client Strategy & Partnership: Partner with Key Account Directors and Business Development to identify opportunities where novel methodology can solve "unsolvable" client problems (e.g., rare disease characterization or complex biomarker validation).
 * Cross-Functional Synergy: Bridge the gap between Data Science, Biostatistics, and Product teams to productize successful novel methods, ensuring they are scalable across the Tempus ecosystem.
 * Project Management & Quality: Ensure all innovative research meets stringent regulatory and ethical standards (e.g., GEP, HIPAA), delivering high-quality results on timelines that match the pace of the biopharma industry.