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# Senior Scientist, Machine Learning Research

- **Company:** A-Alpha Bio, Inc.
- **Location:** Seattle, WA, United States (Remote available)
- **Experience:** Expert
- **Salary:** $164,000.0 - $206,000.0
- **Contract:** Permanent contract
- **Skills:** Artificial Intelligence, Amazon Web Services, Application Frameworks, Cloud Computing, Code Generation, Databases, Information Leak Prevention, Data Transformation, High-Level Architecture, Machine Learning, Language Modeling, Software Engineering, Graph Neural Networks, Pytorch, Large Language Models, Deep Learning, Model Validation, Information Technology, Variational Autoencoders, Stable Diffusion
- **Published:** October 29, 2026
- **Apply:** https://www.juju.com/job/15_349d7c19

## About the Role

Required

 * PhD in a quantitative or life sciences field (biology, chemistry, physics, computer science, etc.) with 4+ years of professional experience in software development and AI/ML, including 2+ years of hands-on experience with AI/ML using biological sequence and/or structure data; or Bachelor's degree in a quantitative or life sciences field with 12+ years of relevant experience, including 6+ years of professional experience in software development and AI/ML; or an equivalent combination of education and experience
 * Strong experience with deep learning, spanning modern software frameworks (PyTorch, JAX), model architectures and approaches (variational autoencoders [VAEs], transformers, graph neural networks [GNNs], diffusion, and flow matching), and common protein engineering tasks (protein language models, inverse folding, and protein structure prediction)
 * Strong proficiency with data science best practices, including wrangling and transforming data, model training, model selection, cross-validation, and deployment at scale
 * Excellent verbal and written communication skills, including the ability to explain methods, findings, and limitations to computational and experimental audiences, as well as to external collaborators and partners

Preferred

 * Expertise with cloud computing, particularly Amazon Web Services (AWS)
 * Proficiency with best practices using large language models (LLMs) and agentic AI tools to assist in code generation and modeling
 * Experience analyzing large experimental datasets and making scientifically defensible decisions about data quality, statistical methods, and interpretation
 * Thorough understanding of concepts from biology, chemistry, and physics that govern molecular properties and interactions
 * Familiarity with the state of the art in antibody engineering, protein engineering, synthetic biology, or other high-throughput biology environments with particular emphasis on the relationship between sequence, structure, and function

## Description

* Develop AI/ML methods. Design and implement novel AI/ML approaches for the prediction and engineering of protein-protein interactions, drawing on experimental measurements, protein sequences, and structural information, and use these approaches to solve challenges in drug discovery and optimization.
 * Evaluate rigorously. Design benchmarks and evaluations that assess model performance, uncertainty, and generalization, using appropriate baselines and guarding against data leakage so that conclusions are scientifically defensible and reproducible.
 * Deliver results. Generate deliverables (such as data packages, model executables, and technical reports) to a level of quality suitable for use within the company and by external collaborators, in accordance with assigned timelines.
 * Contribute code and data. Expertly contribute to the shared company codebase and database, helping teammates understand judgements and decisions, authoring and reviewing merge requests, documenting methods, organizing data, and ensuring that new capabilities and data are effectively rolled out to the rest of the team.
 * Advance our scientific capabilities. Apply scientific discipline and critical thinking to propose and analyze experiments, stay current with emerging technologies and trends, and identify and develop innovative computational approaches that increase the value of AlphaSeq data for protein engineering.
 * Lead, collaborate, and communicate. Take a technical leadership role on assigned projects interfacing across departments, provide mentorship to colleagues, help write and publish technical blog articles or scientific papers, and represent A-Alpha Bio publicly at conferences and/or in scientific discussions with key collaborators.