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# Lead Research Technical Advisor _ SBIR

- **Company:** The University of Rochester
- **Location:** Rochester, NY, United States
- **Experience:** Expert
- **Salary:** $97,400.0 - $146,000.0
- **Contract:** Permanent contract
- **Skills:** Computing Platforms, Software Troubleshooting, Performance Monitor, Data Management
- **Published:** October 26, 2026
- **Apply:** https://www.careerbuilder.com/job-details/lead-research-technical-advisor-sbir-rochester-ny--a9aaa5fd-8258-4b17-8460-9ca3c67454c8

## About the Role

Technical Research, Leadership, Embedded Systems, Biology, Operations Planning, Acquisition Strategy, Microscopy, Translational Research, Instrumentation, Quality Assurance, * Bachelor's degree and 8 years of relevant experience operating and supporting advanced cryo-electron microscopy instrumentation required

 * Or equivalent combination of education and experience
 * Masters in structural biology, biophysics, biochemistry, cell biology, biomedical engineering, or related scientific discipline preferred.
 * PhD in structural biology, biophysics, biochemistry, cell biology, biomedical engineering, or related scientific discipline preferred
 * Demonstrated experience managing complex scientific instrumentation or shared research facilities preferred.

KNOWLEDGE, SKILLS AND ABILITIES

 * Advanced knowledge of cryo-electron microscopy instrumentation, detectors, imaging workflows, and data quality assessment methodologies preferred.
 * Strong troubleshooting, analytical, organizational, and project management skills preferred.
 * Ability to develop SOPs, training programs, and operational policies for a complex shared research resource environment preferred.
 * Excellent written communication and interpersonal skills with the ability to interact effectively with investigators, trainees, vendors, and institutional leadership preferred.
 * Ability to manage multiple priorities independently while maintaining high-quality scientific and operational standards preferred.
 * Demonstrated commitment to collaborative, service-oriented scientific support preferred.
 * Experience with high-resolution cryo-EM data acquisition, sample preparation, and structural biology workflows preferred.
 * Experience with cryo-EM software platforms including EPU, SerialEM, RELION, cryoSPARC, or related analysis environments preferred.
 * Experience with cryo-electron tomography (cryo-ET), micro-ED, cryo-FIB/SEM, or correlative imaging workflows preferred.
 * Experience contributing to grant applications, shared resource operations, or service center leadership preferred.

## Description

Provides scientific, technical, and operational leadership for the Structural Biology Imaging Resource (SBIR) within the Center for Advanced Research Technologies (CART). Oversees the installation, optimization, operation, and long-term development of advanced cryo-electron microscopy instrumentation and associated workflows supporting structural biology and translational research programs. Serves as the institutional subject matter expert in cryo-EM technologies, leading method development, user training, data acquisition strategies, quality assurance, and operational planning for a complex shared research resource. Collaborates extensively with faculty investigators, institutional leadership, external partners, and vendors to advance high-quality, reproducible research and expand institutional cryo-EM capabilities., * Oversee daily operation, optimization, maintenance coordination, and performance monitoring of cryo-EM instrumentation, including the Thermo Fisher Glacios cryo-TEM platform and associated instrumentation.

 * Develop, validate, implement, and continuously optimize cryo-EM workflows, SOPs, quality control procedures, and data acquisition methodologies for single particle analysis, cryo-ET, and related applications.
 * Provide scientific consultation and technical support to investigators regarding experimental design, sample preparation, imaging strategies, data quality assessment, troubleshooting, and interpretation of cryo-EM experiments.
 * Design and deliver user training programs for instrument operation, sample preparation, safety procedures, and best practices; supervise and mentor facility staff and trainees as applicable.
 * Coordinate facility administration including scheduling oversight, service contract management, budgeting, recharge activities, data management coordination, usage reporting, and long-range operational planning.
 * Collaborate with CART leadership, faculty investigators, external vendors, and institutional partners on grant development, technology implementation, methods development, publications, and strategic growth initiatives for the SBIR.
 * Other duties as assigned.