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# Principal Clinical Data Science Lead

- **Company:** ICON plc
- **Location:** UK (Remote available)
- **Experience:** Expert
- **Contract:** Permanent contract
- **Skills:** Clinical Data Management, Clinical Data Repository, Databases, Coherent Remote File System (CRFS), Data Validation, Data Cleansing, Data Control, Database Storage Structures, Metadata, SAS (Software), Information Technology, Data Management
- **Published:** November 3, 2026
- **Apply:** https://dejobs.org/x/x/63CD91EB23614D509FAAF64B95B7A4BE/job/

## About the Role

* Bachelor's degree or equivalent in Natural Sciences, Informatics, Medical Documentation , or a related discipline.
 * 5+ years of experience as a Clinical Data Manager , with significant responsibility within clinical projects and study teams.
 * Strong understanding of the drug development process and extensive experience with clinical data management methodologies and technologies.
 * Proven experience managing clinical data from study start-up through to clean database declaration .
 * Experience working within global, cross-functional teams and collaborating with functions such as Study Management, Medical, EDC Development, Statistics and Medical Writing .
 * Demonstrated ability to interpret Clinical Study Protocols, Statistical Analysis Plans and Medical Review Plans and translate these into appropriate data management specifications.
 * Experience developing specifications including CRFs, metadata, protocol deviation documents and edit check specifications .
 * Good understanding of relevant clinical research regulations and guidelines, including ICH and GCP .
 * Experience training and/or mentoring junior Data Management colleagues, with the ability to provide guidance and act as an escalation point.
 * Experience working within and helping lead global, cross-functional teams towards key study milestones such as First Patient First Visit readiness and timely clean database declaration .
 * Strong written and verbal communication skills in English, with fluent spoken English required, alongside strong local-language communication skills.

## Description

* Leading Clinical Data Management activities across assigned studies, from study start-up through to database closure and clean database declaration.
 * Providing oversight and guidance to Data Management staff assigned to specific protocols, including mentoring and training less experienced colleagues.
 * Acting as an experienced Clinical Data Management resource for global, cross-functional study teams and serving as an escalation point for study-related data management matters.
 * Developing and maintaining study-specific data management components and specifications, including eCRFs, study metadata, edit checks, Data Validation Documents and protocol deviation documentation .
 * Collaborating with EDC developers on the specification and design of eCRFs and database structures and contributing to EDC User Acceptance Testing (UAT).
 * Managing data cleaning activities, including identifying and issuing queries, incorporating query responses, tracking query status and performing consistency checks on external data.
 * Coordinating SAS programming requirements for edit checks and derivations and contributing to the preparation of data monitoring activities.
 * Preparing data listings and extracts to support medical reviews, study reporting and other cross-functional activities.
 * Developing and coordinating database closure plans and ensuring database closure activities are effectively communicated and delivered across the study team.
 * Identifying and communicating issues that could impact study timelines or data quality and working collaboratively with study teams to address them.
 * Ensuring Clinical Data Management activities are appropriately documented throughout the lifecycle of the study.
 * Supporting training and education initiatives for Data Management colleagues to promote quality, productivity and consistent working practices.