> Markdown version of [/jobs/ext/4621225-principal-software-engineer-agentic-platform](https://www.wearedevelopers.com/jobs/ext/4621225-principal-software-engineer-agentic-platform). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Principal Software Engineer, Agentic Platform - **Company:** INSILICO SEARCH PARTNERS, LLC - **Location:** Boston, MA, United States - **Experience:** Expert - **Contract:** Permanent contract - **Skills:** LangGraph Framework, Application Programming Interfaces (APIs), Artificial Intelligence, Amazon Web Services, Cloud Engineering, Distributed Systems, OpenAI, Workflow Management Systems, AWS Cdk, LangChain, Large Language Models, Multi-Agent Systems, Agentic-AI, Event Driven Architecture, Containerization, Kubernetes, CrewAI, AutoGen, Terraform, Api Management - **Published:** November 7, 2026 - **Apply:** https://www.juju.com/job/28_25303_5fc874d74a23e19d4b99c4d7b529f54d ## About the Role * B.S./M.S. in CS, Engineering, or related field, with 10+ years of professional software * Track record architecting and maintaining large-scale distributed systems in production. * Deep expertise in workflow orchestration and event-driven architecture (stateful execution, * Hands-on with agentic AI/orchestration frameworks (LangGraph, LangChain, CrewAI, AutoGen, Pydantic AI). * Experience integrating LLM platforms (Anthropic, OpenAI, Vertex AI, Bedrock) and building agent evaluation/feedback frameworks. * Strong cloud-native engineering on AWS with infrastructure-as-code, containerization, and autoscaling. * Experience designing SDKs, APIs, and data contracts serving multiple downstream teams; proven ability to build consensus and mentor engineers. ## Description Our client is a venture-backed life sciences innovation firm building intelligent software systems that integrate agentic AI with scientific reasoning to accelerate discovery and decision-making, centered on a new autonomous research platform for reasoning over complex biological problems. Own the underlying agentic platform: the durable orchestration layer on which long-running, multi-agent, multi-model scientific workflows run reliably. This is a hands-on architect role for a senior engineer who has built and operated distributed systems at scale and wants to take agentic AI from research to production - setting technical foundation and standards, working shoulder-to-shoulder with AI scientists and engineers, and turning frontier agent patterns into, * Own the agentic platform end to end, from research prototype to production; architect workflow orchestration, evaluation frameworks, and event-driven distributed systems for scale, resilience, and reliability. * Define SDK abstractions and API contracts between model/agent outputs and downstream consumers. * Deliver infrastructure-as-code reference implementations (AWS CDK, Terraform, containerized services), turning AI proof-of-concepts into hardened, reusable patterns. * Own platform cost-efficiency and scalability while preserving performance and accuracy. * Set technical standards and architectural direction; partner across modeling, agent, and product teams and mentor engineers.