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# Machine Learning / Senior Machine Learning Scientist / Engineer

- **Company:** Calico Life Sciences, LLC
- **Location:** South San Francisco, CA, United States
- **Experience:** Expert
- **Contract:** Permanent contract
- **Skills:** Computational Biology, Data Infrastructure, Software Debugging, Machine Learning, Tensorflow, Software Engineering, Pytorch, Deep Learning, Information Technology, Feature Extraction
- **Published:** November 7, 2026
- **Apply:** https://www.juju.com/job/28_25303_34948f1243c71500d79c97ee299d2394

## About the Role

The ideal candidate should be familiar with state-of-the-art machine learning techniques, including language/sequence modeling, representation learning, generative models, and self-supervised learning techniques. Candidates should have experience implementing, extending, and debugging state of the art machine learning models, and have expertise in designing and building robust data infrastructure and tools. Candidates should be independent, self-motivated and be expected to explore relevant ML literature and apply novel approaches to various protein design problems at Calico. Candidates must demonstrate a strong ability to communicate ideas and results through publications and presentations and be able to work cross-functionally to execute on complex projects., Ph.D. in Computer Science, Computational Biology, or related technical field; OR M.S. in Computer Science, Computational Biology, or related technical field, plus 2+ years industry experienceExperience in applying deep learning to model biological sequences and structuresExpert in TensorFlow, PyTorch, and/or JAXStrong software engineering skills and substantial expertise in PythonTrack record of outstanding communication and collaboration in a cross-functional environmentStrong analytical and quantitative skillsMust be willing to work onsite at least four days a week, Domain expertise in computational biology, biochemistry or structural biologyFamiliarity with state of the art structure modeling tools such as AlphaFoldPublic recognition in the field, e.g. via scientific publications or success in machine learning competitionsPrior experience working with biologistsPrior experience working as an ML Engineer/Scientist

## Description

Calico is seeking a machine learning research scientist to develop innovative machine learning algorithms to model and design proteins. This person will work with a team of dedicated experimental biologists to design experiments to test and iteratively refine machine learning predictions.