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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Senior IT Applications Administrator - **Company:** Thermo Fisher Scientific Inc. - **Location:** Cincinnati Metropolitan Area, United States - **Experience:** Expert - **Contract:** Permanent contract - **Skills:** Software Applications, Configuration Management, Information Systems, Data Integrity, Middleware, Laboratory Information Management Systems, Serial Communications, Server Administration, Software Deployment, System Testing, Systems Integration, TCP/IP, Iq/oq/pq, Test Scripts, Information Technology, Health Level Seven International, GXP - **Published:** November 8, 2026 - **Apply:** https://www.careerbuilder.com/job-details/senior-it-applications-administrator--ed3c3b86-3ce0-45cf-bdcf-3e2787db08bd ## About the Role Software Administration, Information Systems/Technology IS/IT Administration, Software Administration, Regulatory Compliance, Laboratory Operations, Documentation, System Lifecycle, Data Quality, Middleware, Quality Assurance, * Bachelor's degree in IT, Computer Science, Engineering, Clinical Laboratory Science, Medical Technology, or a related field; equivalent experience may be considered. * 5+ years of experience supporting regulated laboratory, healthcare, clinical, or manufacturing applications. * 3+ years of experience with laboratory instruments, middleware, LIS, or medical device integrations. * Experience with GxP environments, CSV, IQ/OQ/PQ, change control, validation documentation, and audit support. * Knowledge of TCP/IP, serial communications, interface troubleshooting, and configuration management., * Experience with Instrument Manager or comparable laboratory middleware. * Knowledge of HL7, ASTM, GAMP 5, laboratory workflows, and quality control systems. * Experience with audit trails, data integrity assessments, assay validation, and reportable ranges. * Experience in clinical laboratories, pharmaceutical, biotechnology, CRO, or medical device environments. Regulatory Knowledge: 21 CFR Part 11 * GxP * GCP * GLP * GDP * CSV * ALCOA+ * Change Control * CAPA * Deviation Management, * Frequently stationary for 6-8 hours per day. * Repetitive hand movement of both hands. * Frequent mobility required. * Occasional crouching, stooping, bending and twisting. * Light to moderate lifting and carrying up to 15-20 lbs. * Ability to use a variety of computer software. * Ability to communicate information and ideas effectively, with the ability to listen to, and understand, information and ideas presented through spoken words and sentences. * Frequently interacts with others to obtain or relate information to diverse groups. * Ability to multitask and perform under stress. * Regular and consistent attendance. ## Description The Senior Application Administrator is responsible for administering, configuring, validating, and supporting laboratory middleware, LIS applications, and instrument interfaces within a regulated GxP environment. This role ensures reliable instrument-to-LIS integrations, data integrity, regulatory compliance, and appropriate system lifecycle documentation. The position works closely with Laboratory Operations, Quality Assurance, Validation, and IT teams. * Must be legally authorized to work in the United States without sponsorship. * Must be able to pass a comprehensive background check, which includes a drug screening(where applicable) * Greater Cincinnati/Northern KY location required, Relocation assistance is not provided. Purpose: * Administer and support laboratory middleware, LIS applications, and instrument interfaces. * Configure instrument connections, test/code mappings, routing rules, communication parameters, and application settings. * Support onboarding and implementation of new instruments, analyzers, assays, and laboratory interfaces. * Manage configurations across Development, Test, Validation, and Production environments. * Troubleshoot interface, connectivity, mapping, transmission, and data integrity issues. * Execute Computer System Validation (CSV) activities, including IQ, OQ, and PQ. * Develop and execute validation protocols, test scripts, traceability documentation, and validation evidence. * Perform end-to-end testing from instrument processing through middleware and LIS reporting. * Review logs, audit trails, interface transactions, and reports to verify data integrity. * Support change controls, risk assessments, system upgrades, configuration changes, and production deployments. * Maintain compliance with 21 CFR Part 11, GxP, GDP, ALCOA+, and company quality procedures. * Maintain audit-ready documentation and support internal and regulatory inspections. * Collaborate with Laboratory Operations, QA, Validation, and IT teams and provide technical guidance to junior administrators.