> Markdown version of [/jobs/ext/4692878-principal-it-applications-analyst-lab-systems](https://www.wearedevelopers.com/jobs/ext/4692878-principal-it-applications-analyst-lab-systems). Every page supports `.md` or `Accept: text/markdown`. Links point to the HTML versions so they work for humans too. Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md).

---

# Principal IT Applications Analyst - Lab Systems

- **Company:** Regeneron
- **Location:** Rensselaer, NY, United States
- **Experience:** Expert
- **Salary:** $94,000 - $179,500
- **Contract:** Permanent contract
- **Skills:** Software Applications, Application Performance Management, Information Systems, Databases, Continuous Integration, Data Integrity, Domain Name System (DNS), Traceroute, Python (Programming Language), Name Server, Networking Basics, Network Diagnostics, Packet Analyzer, Windows PowerShell, Release Management, Server Administration, Data Streaming, TCP/IP, Wireshark, Scripting, Transport Layer Security, Load Balancing, Sql Optimization, Firewalls (Computer Science), Information Technology, 3-tier Architectures, Firewall Services Module, Network Server, GXP
- **Published:** November 12, 2026
- **Apply:** https://www.careerbuilder.com/job-details/principal-it-applications-analyst-lab-systems-rensselaer-ny--85d8d63f-7012-4fdb-ac9d-300e55550ac2

## About the Role

Information Technology & Information Systems, Laboratory Systems, Laboratory Analysis, Continuous Improvement, Cross-Functional, Corrective Action, Software Administration, Information Technology & Information Systems, Analysis Skills, Medical Products, * Bachelor's degree in Information Technology, Computer Science, or related degree

 * Principal IT Applications Analyst: 8+ years work experience
 * Staff IT Applications Analyst: 10+ years work experience
 * May consider equivalent combination of education and experience; level determined based on qualifications
 * Working knowledge of networking fundamentals including TCP/IP, DNS, TLS/certificates, firewalls, port requirements, and load balancing sufficient to troubleshoot application connectivity issues
 * Advanced SQL proficiency and scripting experience in Python, PowerShell, or similar languages
 * Working knowledge of change control and structured release management
 * Experience in a regulated environment including GxP or 21 CFR Part 11 preferred
 * Experience with network diagnostic tooling such as Wireshark, packet captures, or traceroute preferred
 * Familiarity with CI/CD practices for configuration promotion and experience supporting systems across US and EU time zones a plus

## Description

* Deliver Tier 3 application support including root cause analysis and implementation of permanent corrective actions; diagnose network-related issues affecting application performance and availability including connectivity, name resolution, certificates, and firewall rules in partnership with network and infrastructure teams
 * Configure, test, and promote changes through controlled environments in accordance with change management and release procedures; support system integrations including diagnosis and resolution of data flow and interface failures across servers, databases, and connected systems
 * Develop and execute test documentation, maintaining traceability from requirements through objective evidence; provide audit support with clear, traceable evidence covering access controls, change history, and data integrity
 * Collaborate with business owners to translate requests into well-defined, prioritized work; communicate complex technical issues clearly and effectively to non-technical stakeholders at all levels
 * Mentor junior analysts and maintain operational runbooks to ensure knowledge is shared and sustained across the team