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# Staff Scientist I, Data Science

- **Company:** Lieber Institute Inc
- **Location:** Baltimore, MD, United States
- **Experience:** Experienced
- **Salary:** $82,000 - $87,000
- **Contract:** Permanent contract
- **Skills:** Bioinformatics, Computational Biology, Computer Programming, Linux, Python (Programming Language), High Performance Computing, Software Version Control
- **Published:** November 12, 2026
- **Apply:** https://www.thejobnetwork.com/job/7505cc08-1a47-4287-8e86-d6155881a691/staff-scientist-i-data-science

## About the Role

· Master's Degree or higher (PhD Preferred) in Computational Biology, Bioinformatics, Biostatistics, Genetics, Neuroscience, or related field is required.

· A minimum of 2 years related experience.

Special Knowledge, Skills, and Abilities:

· Proficiency in Linux and programming with R or Python

· Demonstrated experience analyzing large-scale transcriptomic or other genomic datasets, particularly single-nucleus and spatial transcriptomics data.

· Strong understanding of statistical analysis, including experimental design, regression or mixed-effects models, multiple testing, and sources of technical and biological variation.

· Familiarity with high-performance computing, version control, and reproducible analysis practices.

· Ability to independently develop analytical strategies, troubleshoot computational problems, and critically evaluate results.

· Expertise to ask and interpret biological questions underlying the data and ability to communicate findings clearly to colleagues with varied computational and experimental backgrounds is highly desired.

· Previous experience working on genomics datasets related to neuroscience or psychiatry is preferred but not required.

Physical Requirements:

· Incumbent is required to work in an office environment.

· Must be able to move about the office and campus as well as remain stationary for extended periods of time.

· Ability to continuously operate a personal computer for extended periods of time.

· Visual acuity as well as mental acuity sufficient to collect and interpret data, evaluate, reason, define problems, establish facts, draw valid conclusions, make valid judgments and decisions are required

· Ability to speak and hear well enough to communicate clearly and understandably with sufficient volume to ensure an accurate exchange of information in normal conversational distance, over the telephone, and in a group setting

· Physical dexterity sufficient to use hands, arms, and shoulders repetitively to operate a keyboard and other office equipment, use a telephone, access file cabinets and other items stored at various levels, including overhead

· Ability to lift or move objects up to 25 lbs.

## Description

A Staff Scientist position in computational biology and bioinformatics is available to work within the Neural Plasticity division at the Lieber Institute for Brain Development (LIBD). Our research investigates the molecular organization, development, and function of brain circuits involved in psychiatric disorders. We combine molecular profiling of postmortem human brain tissue with experimental mouse studies and human induced pluripotent stem cell (iPSC) and organoid models to understand how distinct neuronal populations contribute to brain function and disease, with the goal of discovering novel therapeutic targets.

The successful candidate will lead analyses of single-nucleus RNA sequencing, spatial transcriptomics, and other multiomic datasets generated by our team and collaborators. This position offers opportunities to develop computational approaches, shape research questions, and work closely with experimental scientists to connect molecular findings with cellular organization, circuit function, and behavior.

Specific Duties and Responsibilities:

· Analyze and interpret large-scale genomic and multiomic datasets from human brain tissue, mouse and organoid models, and public resources.

· Develop and apply computational and statistical approaches to address research questions in neuroscience and psychiatric disorders.

· Develop and maintain reproducible analysis workflows, with responsibility for data quality, documentation, and organization.

· Prepare scientific figures, write and revise manuscripts, and contribute to grant applications in collaboration with research teams.

· Present research findings at team meetings and scientific conferences.

· Other duties as assigned.