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# Job offer

- **Company:** Hospital del Mar Research Institute
- **Location:** Barcelona, Spain
- **Contract:** Temporary contract
- **Skills:** Data Analysis, Bioinformatics, Molecular Modeling
- **Published:** November 13, 2026
- **Apply:** https://researchmar.net/ofertes/es_detall-oferta-temporals.html?id=3455

## About the Role

PhD or equivalent, Academic background

 - Master's degree in Bioinformatics for Health Sciences.
 - Admission to an accredited PhD programme at the time of recruitment, followed by formal proof of enrolment.

Technical skills and knowledge

 - Strong background in structural biology, structural bioinformatics and G protein-coupled receptor (GPCR) biology.
 - Experience in molecular modelling and molecular dynamics simulations.
 - Familiarity with molecular simulation software such as ACEMD, OpenMM or GROMACS.
 - Knowledge of protein-ligand interactions, molecular recognition and structure-based drug discovery.
 - Knowledge of Python programming and the analysis of large molecular datasets.
 - Experience with computational workflows and scientific data analysis.
Specific Requirements

Additional assets

 - Experimental experience in structural biology, particularly involving GPCRs.
 - Previous research experience in computational drug discovery or molecular pharmacology.
 - Familiarity with virtual screening and high-performance computing (HPC) environments.

Personal competencies

 - Strong analytical thinking and problem-solving skills.
 - Motivation to pursue a career in scientific research.
 - Ability to work independently and collaboratively within a multidisciplinary team.
 - Excellent written and spoken English.
 - Strong communication, organisational and scientific reporting skills.

Languages
ENGLISH

## Description

The Research Institute of the Hospital del Mar is looking for a Predoctoral Researcher (FPI) to join the Research
Group in the discovery of drugs based on receptors coupled to G proteins, led by JANA SELENT -, located at the
Biomedical Research Park (PRBB) in Barcelona.

This PhD research project focuses on understanding how cancer-associated mutations alter the structure, dynamics,
and pharmacological properties of G protein-coupled receptors (GPCRs). These mutations can modify receptor
conformational landscapes, influencing receptor stability, signaling pathways, and ligand recognition. The project
aims to identify compounds capable of selectively targeting oncogenic GPCR variants and restoring dysfunctional
receptor states. By combining molecular dynamics simulations, structural bioinformatics, ensemble-based virtual
screening, and ligand-receptor interaction analysis, the research will contribute to the development of precision
therapeutic strategies for different cancer types.