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Agent guide: [/agents.md](https://www.wearedevelopers.com/agents.md). --- # Senior Scientist I, DMPK - **Company:** Wave Life Sciences - **Location:** Lexington, MA, United States - **Experience:** Expert - **Salary:** $157,000.0 - $213,000.0 - **Contract:** Permanent contract - **Skills:** Software Tools, WinNonlin Software, Modeling and Simulation - **Published:** June 25, 2026 - **Apply:** https://ectf.fa.us2.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1/requisitions/preview/481/?mode=location ## About the Role Wave Life Sciences is seeking a highly motivated and detail-oriented Scientist with strong expertise in bioanalytical and Drug Metabolism and Pharmacokinetics (DMPK) sciences to support drug development programs from preclinical through clinical stages. The successful candidate will play a key role in independently designing, executing, and interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in vitro drug-drug interaction (DDI) studies. This role will be based in our Lexington, MA office with a hybrid work arrangement., * Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or related discipline with at least 3 years of relevant experience, or M.S. with at least 6 years of industry experience * The ideal candidate will have experience supporting the development of RNA-based modalities (e.g., siRNA, antisense oligonucleotides, GalNAc conjugates, etc.), * Proficient in PK software tools such as Phoenix WinNonlin and conduct NCA * Conduct graphical analysis using standard tools like Phoenix WinNonlin, R, or similar * Demonstrate sound knowledge of PK/PD principles * Familiarity with regulatory requirements for nonclinical DMPK studies * Demonstrate expertise in plasma protein binding and in vitro DDI assessments (e.g., CYP inhibition/induction, transporter interactions) * Ability to innovate and think creatively to support the drug development process * Excellent communication, organizational, and teamwork skills * Knowledge and experience in bioanalysis to support DMPK studies (metabolite identification, biodistribution, etc.) * Hands-on experience with modeling and simulation is a plus ## Description * Independently design, execute, and interpret in vitro and in vivo studies (i.e., ADME, PK, PK/PD) to support advancement of RNA therapeutic programs * Autonomously analyze and interpret PK, TK and PK/PD data using appropriate software tools (e.g., Phoenix WinNonlin), including conducting NCA and graphical exposure-response analyses * Represent DMPK function at cross-functional project team meetings * With guidance, plan, execute, and deliver DMPK deliverables from lead selection to IND stage * Collaborate with cross-functional teams including bioanalysis, discovery research, toxicology, clinical pharmacology, regulatory, and external CROs to meet program goals and timelines * Prepare high-quality scientific reports and integrate DMPK data into regulatory documents (IND, CTA, briefing documents, etc.) * Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data * Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings * Stay current with regulatory guidance and scientific advances in the field of bioanalysis and DMPK ## Related Videos - [DOOM on Neurons, Training AI with Harry Potter & Robots Watching YouTube - Zoran Jambor](https://www.wearedevelopers.com/videos/1823-doom-on-neurons-training-ai-with-harry-potter-robots-watching-youtube-zoran-jambor) - [ Secure Code Superstars: Empowering Developers and Surpassing Security Challenges Together](https://www.wearedevelopers.com/videos/422-secure-code-superstars-empowering-developers-and-surpassing-security-challenges-together) - [Geometric deep learning for drug discovery](https://www.wearedevelopers.com/videos/264-geometric-deep-learning-for-drug-discovery) - [Localized Open Models in Production: What Builders Need to Know](https://www.wearedevelopers.com/videos/100270-localized-open-models-in-production-what-builders-need-to-know) - [Old tools, new tricks](https://www.wearedevelopers.com/videos/1916-old-tools-new-tricks) - [Data Science, ML & AI in the Oil and Gas Industry at NDT Global - Dr. Katja Träumner](https://www.wearedevelopers.com/videos/1308-data-science-ml-ai-in-the-oil-and-gas-industry-at-ndt-global-dr-katja-traumner) ## Related Articles - [Everything a Developer Needs to Know About MCP with Neo4j](https://www.wearedevelopers.com/magazine/604-everything-a-developer-needs-to-know-about-mcp-with-neo4j) - [The Biggest German Tech Companies](https://www.wearedevelopers.com/magazine/424-the-biggest-german-tech-companies) - [Fully Remote Software Engineer Jobs](https://www.wearedevelopers.com/magazine/447-fully-remote-software-engineer-jobs) - [Résumé-Driven Development: How IT trends affect the job market for software developers](https://www.wearedevelopers.com/magazine/59-resume-driven-development-how-it-trends-affect-the-job-market-for-software-developers) - [Data Analyst Salary in the UK](https://www.wearedevelopers.com/magazine/278-data-analyst-salary-in-the-uk) - [Find a Developer Job: 12 Best Job Sites For Developers](https://www.wearedevelopers.com/magazine/165-find-a-developer-job-12-best-job-sites-for-developers)