Principal Manufacturing Systems Engineer

Lets do this. Lets change the world. In this vital role, you will drive overall program success by applying program and project management principles to teams, partnering with business and technology leaders to ensure comprehensive alignment, and finding optimized ways to deliver efficiency and quality for our partners., We are seeking a Principal Manufacturing Systems Engineer with solid leadership skills in any of Amgen Manufacturing locations in the US or Europe to join our Ops Technology Manufacturing & Engineering team to help drive productivity through the company using technology to unlock opportunities to stop, optimize processes and then automate as appropriate. Are you someone that has extensive experience on the Operations technology (Aveva Pi, DeltaV, Rockwell, MES) and Program Management to take progressive project management approaches. Are you eager to take your program management, continuous improvement & SAFE-Agile, financial management skills and use them in creative new ways to build groundbreaking Operation smart technologies that helps develop life-changing biotech medicines?, If so, this may be the right place for you., * Lead large capital project and product teams by fostering Agile delivery while operating within GMP manufacturing environments.

• Partner with site and global stakeholders to prioritize demand, manage backlogs, and balance local needs with global strategy.
• Accountable for financials, resource planning, vendor performance, and delivery against scope, schedule, and quality targets.
• Drive global standards, templates, and best practices for large operations technology project and product design, deployment, lifecycle management, and support to enable scalability and operational excellence.
• Ensure solution delivery meets GMP compliance, data integrity, electronic batch records, and regulatory inspection readiness requirements.
• Lead cross-functional collaboration between site and corporate Operations, Quality, IT, OT, Automation, Platform Owners, and external system integrators.
• Own the global operations technology roadmap, including upgrades, standardization, harmonization, and site deployments, aligned with business and regulatory requirements.
• Mentor and coach junior project managers or Scrum Masters.
• Present status updates and progress to senior leadership at various governance meetings.

A day in a life:

• You are leading from the front, engaging with business functions across the company to help deliver core manufacturing systems.
• Partnering with strategy groups at Amgen and business partners to deliver initiatives.
• Lead a team of PMs, Platform SMEs, and communication resources to ensure structure in how the program operates.
• Drive financial compliance and adherence across the program through the various projects.
• Own the overall program roadmap and communicate program status and milestones to executive leadership.
• Ensure product teams operate in the spirit of Agile and have backlogs that are being managed optimally.

Doctorate degree and 2 years of Manufacturing automation/Information systems leadership experience, Masters degree and 4 years of Manufacturing automation/Information systems leadership experience, Bachelors degree and 6 years of Manufacturing automation/Information systems leadership experience, Associates degree and 10 years of Manufacturing automation/Information systems leadership experience, High school diploma / GED and 12 years of Manufacturing automation/Information systems leadership experience, * Program and project management and delivery experience around manufacturing core systems like Aveva PI, DeltaV, Rockwell, Korber MES, Digital Infrastructure, and advanced digital smart technologies.

• Solid understanding of GAMP software development lifecycle, ANSI/ISA-S88 and S95 industry standards and methodologies, and 21 CFR Part 11.
• Fluent in Agile methodologies with respect to technology solutions, their development, and timelines.
• Experience as a Product Owner or Scrum Master is a must.
• Manage integration of OT platforms (MES, PI data, etc.) with core manufacturing and enterprise systems (ERP, LIMS, historians, automation layers such as DeltaV and Rockwell, and data platforms).
• Strong written and oral communication skills with scientific domain expertise to communicate effectively with various partners within the organization.
• Self-motivated individual with demonstrated ability to learn new concepts and technologies and work cross-functionally in teams, both internal and external.
• Project finance experience.
• You will have a consultant attitude, with the ability to clarify and control a diverse and shifting program lifecycle. Creativity and flexibility will be key components to excelling in this role.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career., As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease., We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world's leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide. We live the mission. We win together. We thrive on continual challenge. Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together-to research, manufacture and deliver ever-better products and greater depth to our mission. At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we're transforming the promise of science and biotechnology into therapies that have the power to restore health. Connect with us to explore how you can Win, Live, and Thrive at Amgen.