Scientist I, Immune Evasion

Scientist I, Immune Evasion. Advancing Dyno's immune evasion capabilities by developing and executing innovative assay strategies that enable the discovery and clinical readiness of next-generation capsids., As a Scientist I, you will independently lead and evolve Dyno's high-throughput immune evasion assay platform, driving antibody evasion studies that support CNS and Muscle capsid discovery programs and partnering cross-functionally to shape experimental strategy and address technical gaps. You will also help expand the team's immune evasion capabilities beyond pre-existing antibodies to emerging clinical readiness challenges, including re-dosing, T-cell responses, complement activation, and innate immunity. At Dyno, every role is mission-driven. Whether in science, engineering, operations, or business, each AAViator contributes to solving some of the most complex challenges in genetic medicine. Responsibilities:

• Independently execute and support high-throughput immune evasion (IE) assays, including antibody neutralization and total antibody immunoprecipitation (tAb IP) workflows, to ensure uninterrupted support for CNS and Muscle capsid discovery programs.
• Own the day-to-day operation, optimization, and troubleshooting of immune evasion assay platforms, iteratively refining workflows and developing new assay formats in response to evolving program needs and emerging data.
• Analyze, interpret, and communicate immune evasion screening data to cross-functional stakeholders, helping inform capsid selection and discovery strategy.
• Contribute to the expansion of Dyno's immune evasion capabilities beyond antibody neutralization by reviewing literature, proposing experimental approaches, and conducting feasibility studies related to re-dosing, T-cell responses, complement activation, and innate immunity.
• Partner closely with Immune Evasion, CNS, Muscle, and in vivo teams to identify technical gaps, improve assay throughput and robustness, and accelerate progress toward clinically ready capsids.
• Support the long-term development of internal immune evasion discovery capabilities, including high-throughput library cloning and production workflows, to increase team self-sufficiency and create additional bandwidth for receptor-targeted capsid discovery efforts.

• Ph.D. (or equivalent experience) in Immunology, Cell/Molecular Biology, or a closely related discipline, with deep understanding of immune mechanisms relevant to gene therapy (e.g., humoral immunity, antigen presentation, immune cell activation).
• Hands-on experience with immunological assays (e.g., immunoprecipitation, ELISA, neutralization, ELISPOT assays) and molecular biology techniques (qPCR, flow cytometry, NGS library prep, NGS-based experimental design).
• Prior experience with antibody biology and/or adaptive immune responses (e.g., B-cell/T-cell biology, serology, neutralization mechanisms). This is directly relevant to the team's core mandate.
• Strong experimental design skills and the ability to independently troubleshoot complex, multi-step assay workflows.
• Ability to critically evaluate scientific literature and translate findings into actionable experimental hypotheses.
• Foundational knowledge of statistical methods for data analysis and hypothesis testing.
• Effective scientific communicator-able to present results clearly to both technical and cross-functional audiences., * Familiarity with in vivo models of immune response or experience interpreting in vivo immunogenicity data in the context of gene therapy or biologics.
• Prior experience designing and working with high-throughput libraries (DNA/molecular) or large-scale screening workflows.
• Working knowledge of Python or R for data analysis; comfort with large datasets from NGS or high-throughput screening.
• Exposure to AAV biology, gene therapy, or viral vector engineering.

• Competitive compensation & equity-your contributions drive results, and we pay accordingly.
• Mission-aligned, high-trust environment-we succeed together, supporting each other through challenges.
• A career-defining experience-work at the forefront of AI-driven genetic medicine, tackling problems that reshape healthcare.

If you're ready to push boundaries, build the future, and thrive in a fast-moving, high-impact environment-we'd love to hear from you. At Dyno, we believe in transparent and equitable compensation practices. Base Salary Range: $123,807.01 - $148,568.41/year This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact. This role is eligible for:

• Annual performance-based bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-campus gym membership, onsite lunch, commuter support, and company provided laptop

At Dyno Therapeutics, we are a high-energy, high-impact team on a mission to build high-performance genetic technologies that transform patient lives. Our team unites world-class molecular biologists, protein engineers, software developers, data scientists, and machine learning experts-all working together at the intersection of AI and genetic medicine. Our culture is defined by three core values that guide everything we do: * One Mission: Everything we do is for the mission. We are a cohesive and motivated team, thinking ahead and supporting one another to overcome challenges. * Proactive Responsibility: We take action, inject energy into our work, and hold ourselves accountable for delivering results. * Reaching for Excellence: We constantly strive for excellence, fueled by curiosity, adaptability, and the courage to speak hard truths in pursuit of success. These values are more than words-they drive our actions and decisions. Our greatest strength isn't technology-it's our work ethic. More than just technologists, we're a team of relentlessly resourceful problem-solvers: with an unshakable drive we generate breakthroughs at the intersection of AI and genetic medicine. What You'll Give: * Bring an unstoppable work ethic, stepping up when things get tough and adapting as priorities shift. * Embrace challenges as opportunities, finding solutions where none exist and driving innovation forward. * Operate with urgency, responsibility, and resilience, because this mission demands the best from us., + Watertown, MA + $100,000-110,000 per year About the ALS Therapy Development Institute The ALS Therapy Development Institute (ALS TDI) is the world's leading nonprofit biotech focused exclusively on discovering and develo… + 19 days ago, © 2026 Careerjet All rights reserved