Senior Manager MES System

Platform Ownership & Strategy

• Own the MES platform end-to-end, including PAS-X core, integrations, infrastructure, and supporting services.

• Define and execute the MES platform strategy aligned with site and enterprise manufacturing priorities.

• Establish andmaintaina multi-year MES roadmap covering sustainment, modernization, scalability, and technical debt reduction.

• Serve as the single accountable decision owner for MES platform architecture, risk, and trade-offs.

DevOps & Operational Excellence

• Own the DevOps operating model for MES, including incident, problem, change, release, and deployment management.

• Ensure high availability, performance, and reliability of MES in a 24x7 GMP manufacturing environment.

• Lead root cause analysis for critical incidents and drive systemic corrective and preventive actions.

• Oversee system upgrades, patches, enhancements, and infrastructure changes with minimal manufacturing disruption.

• Define andmonitoroperational SLAs, KPIs, and reliability metrics.

Compliance, Validation & Quality

• Own the MES validation strategy (IQ/OQ/PQ) in alignment withGxP, GAMP 5, and 21 CFR Part 11 requirements.

• Ensure continuousinspectionreadiness through strong documentation, controls, and operating discipline.

• Partner with Quality to ensure compliance is embedded in solution design, delivery, and operations.

• Accountable for audit readiness, support, responses, observations, and remediation related to MES.

Delivery & Continuous Improvement

• Govern intake, prioritization, and delivery of MES enhancements and business requests.

• Balancerunand change demand to ensure predictable delivery without compromising system stability.

• Drive standardization, simplification, and reuse across MES workflows and configurations.

• Identifyand sponsor opportunities for automation, analytics, and AI-enabled improvements.

People Leadership

• Lead, coach, and develop a multi-disciplinary MES DevOps and development team.

• Set clear roles, expectations, and accountability across support, development, and delivery functions.

• Build team capability and resilience through succession planning, cross-training, and skills development.

• Foster a culture of ownership, quality, continuous improvement, and collaboration.

Stakeholder & Financial Management

• Serve as a senior interfacetoManufacturing, Packaging, Quality, Automation, Warehouse, and IT leadership.

• Bachelor's degree in IT, Engineering, Computer Science, ora relateddiscipline (or equivalent experience).

• 10+ years of experience supporting or leading MES or manufacturing systems in a regulated (GxP) environment.

• Demonstrated experience owning and operating mission-critical platforms in a 24x7 environment.

• Proven people management experience leading technical teams.

• Strong working knowledge of PAS-X MES platforms.

Preferred Qualifications

• ExperienceestablishingDevOps or product-centric operating models in regulated manufacturing.

• Direct accountability for audits, inspections, and regulatory interactions related to MES.

• Experience managing both run and change budgets for large enterprise platforms.

• Knowledge of SAP-MES integration, ISA-95 / S88, and OT/automation interfaces.

• Certification inPAS-XMES systems.

• Experience with leveraging AI/ML.

• Strong executive communication and stakeholder management skills.

The salary range for this position is: $153,935.00 - $199,210.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

Gilead Sciences, Inc. (La Verne, CA) At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together., Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.