Scientist l - LBA (Ligand Binding Assay) Ops

We are seeking an independent, knowledgeable, and highly motivated Ligand Binding Assay Scientist (Scientist I) to join theQuantitative Translational and ADME Sciences (QTAS) department at Abbvie Bioresearch Center in Worcester, MA.

The LBA Operations Bioanalytical team at ABC QTAS conducts non-regulated, pre-clinical quantitative bioanalysis assays of large molecule therapeutics like monoclonal antibodies (mAb), multi-specific Abs, antibody-drug conjugates (ADC), antibody oligonucleotide conjugates (AOCs), and fusion proteins for Pharmacokinetic (PK), Pharmacodynamic (PD) and Toxicokinetic (TK) studies using ligand binding assays to support early development and drug discovery efforts.

As a Scientist I, you will be responsible for: 1) Conducting pre-clinical sample analysis using ligand binding assays (MSD, ELISA) manually and using automated liquid handlers 2) Updating sample, protocol, and reagent management systems using electronic tools such as Laboratory Information Management System (rLIMS) and e-notebooks 3) Reporting, discussing, and QCing results to project teams which enable pharmacokinetic and pharmacodynamic analysis in support of oncology, immunology, neurology, and other AbbVie therapeutic portfolios.

The ideal candidate will be a self-motivated, highly adaptable scientist with strong attention to details, has the ability to quickly learn new concepts, and a commitment to clear, consistent communication in a fast-paced, dynamic environment., * Analyze samples by ligand binding assays (PK, PD, TK, ADA) using Meso Scale Discovery platform and colorimetric ELISA or other assay platforms.

• Plan and execute sample analysis based on bioanalytical protocols and in vivo study designs on a variety of biological matrices (tissue lysates, serum, others) from a variety of species (monkey, mouse, rat).
• Analyze pre-clinical in vivo samples based on a dynamically changing operational schedule.
• Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy.
• Perform timely, accurate, and thorough data archiving in ELN and rLIMS.
• Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams
• Actively support day-to-day laboratory operations.
• Write and update experimental protocols and procedures.
• Independently and efficiently initiate, design, interpret, and troubleshoot operational assays.

• Bachelors degree in biology, biochemistry, pharmacology, or related field with at least 5 years of pharmaceutical experience or MS in mentioned fields with 2+ years of relevant experience.
• Experience with ligand binding workflow and assay development and troubleshooting is required.
• Strong attention to detail, with demonstrated impact as an independent and self-motivated contributor.
• Ability to operate and maintain laboratory equipment and reagents/material inventories independently.
• Experience with lab automation is desirable.
• Proven independence and problem-solving ability.
• Excellent written and verbal communication skills and ability to draft technical reports.
• Proficiency with computers and data analysis/documentation software including Excel, LIMS, and ELN.
• Ability to summarize, communicate, and interpret bioanalytical results.
• Ability and willingness to work effectively in a highly collaborative and multidisciplinary environment.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this roleat thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on manyfactors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may bemodified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipate in our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount isearned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat areallocable to a particular employeeremains in the Company'ssoleandabsolutediscretion unless and until paid andmay bemodified at the Companys sole and absolutediscretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.