Principal Software Engineer

As we continue to grow and expand our services, we are seeking an accomplished Principal Software Engineer to work ONSITE to serve as a technical leader and architect across our software ecosystem. This role is responsible for driving the design, scalability, and evolution of mission-critical systems that support genetic testing workflows, clinical reporting, and data-driven insights. The ideal candidate combines deep technical expertise with strong leadership, systems thinking, and the ability to influence engineering direction across teams. This position will collaborate closely with geneticists, bioinformaticians, laboratory professionals, and product leaders to deliver robust, secure, and innovative software solutions that directly impact patient care.

KEY RESPONSIBILITES

Lead the architecture, design, and development of complex software systems and platforms

Define and champion engineering standards, best practices, and long-term technical roadmaps

Collaborate with cross-functional teams to translate business needs into scalable, secure, and maintainable solutions

Conduct deep technical reviews, guide system design discussions, and ensure architectural consistency across teams

Mentor and coach engineers, fostering a culture of technical excellence and continuous learning

Drive root-cause analysis and resolution of complex technical issues, ensuring system reliability and data integrity

Evaluate emerging technologies and guide strategic adoption where appropriate

Partner with product, laboratory, and bioinformatics teams to optimize workflows and enhance operational efficiency

Ensure compliance with security, privacy, and regulatory requirements across all software systems

Contribute to innovation initiatives that advance Baylor Genetics' digital capabilities and competitive advantage

Perform other duties as assigned to support team and organizational objectives.

Comply with all company policies, procedures, and applicable regulatory requirements.

Required

B.S. in Computer Science or related field required

10+ years of professional software engineering experience, including significant experience in large-scale or complex systems

Expert-level proficiency with C# and .NET (e.g., .NET Core / .NET 6+)

Extensive experience architecting and building React + TypeScript applications

Deep expertise with relational databases such as MS SQL Server, PostgreSQL, or MySQL, including schema design, performance tuning, and data modeling

Proven experience designing, implementing, and governing RESTful APIs and distributed systems

Strong background in software architecture, system design, and engineering best practices

Demonstrated experience leading technical initiatives, mentoring engineers, and influencing cross-functional decision-making

Strong understanding of DevOps principles, CI/CD pipelines, and cloud-native architectures

Excellent analytical and problem-solving skills with the ability to navigate ambiguity and complexity

Equivalent combination of education and experience may be considered.

Preferred:

M.S. or higher preferred in Computer Science or related field

Experience in healthcare, clinical diagnostics, genomics, or NGS environments

Familiarity with laboratory workflows, LIMS systems, or clinical reportingplatforms

Experience working in regulated environments (CLIA, CAP, HIPAA)

Background in designing secure, compliant, and audit-ready systems

Experience with high-performance or data-intensive applications, including optimization and scalability strategies

COMPETENCIES

A strategic technical leader who can define long-term architectural direction

Strong ownership mindset with the ability to drive initiatives from concept to production

Exceptional communication skills, capable of translating complex technical concepts for diverse audiences

A collaborative partner who elevates team performance and mentors engineers at all levels

Sound judgment balancing innovation, speed, quality, and regulatory requirements

Passion for building systems that directly support clinical decision-making and patient outcomes

PHYSICAL DEMANDS AND WORK ENVIRONMENT

Location: Onsite

Physical demands for the job (e.g., Must be able to lift 25 lbs, standing for prolonged periods of time, etc.)